Global DNA methylation changes spanning puberty are near predicted estrogen-responsive genes and enriched for genes involved in endocrine and immune processes

Clinical Epigenetics
Emma E ThompsonCarole Ober

Abstract

The changes that occur during puberty have been implicated in susceptibility to a wide range of diseases later in life, many of which are characterized by sex-specific differences in prevalence. Both genetic and environmental factors have been associated with the onset or delay of puberty, and recent evidence has suggested a role for epigenetic changes in the initiation of puberty as well. To identify global DNA methylation changes that arise across the window of puberty in girls and boys. Genome-wide DNA methylation levels were measured using the Infinium 450K array. We focused our studies on peripheral blood mononuclear cells (PBMCs) from 30 girls and 25 boys pre- and post-puberty (8 and 14 years, respectively), in whom puberty status was confirmed by Tanner staging. Our study revealed 347 differentially methylated probes (DMPs) in females and 50 DMPs in males between the ages of 8 and 14 years (FDR 5%). The female DMPs were in or near 312 unique genes, which were over-represented for having high affinity estrogen response elements (permutation P < 2.0 × 10-6), suggesting that some of the effects of estrogen signaling in puberty are modified through epigenetic mechanisms. Ingenuity Pathway Analysis (IPA) of the 312 genes near...Continue Reading

References

Jun 1, 1979·Metabolism: Clinical and Experimental·J A MorrisonC J Glueck
Feb 1, 1970·Archives of Disease in Childhood·W A Marshall, J M Tanner
Jun 1, 1969·Archives of Disease in Childhood·W A Marshall, J M Tanner
Feb 1, 1997·Pediatric Research·L TaittonenM Nuutinen
May 4, 2002·Best Practice & Research. Clinical Endocrinology & Metabolism·Laura C Alonso, Robert L Rosenfield
Apr 12, 2003·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Robert F Lemanske
Oct 18, 2003·The Journal of Allergy and Clinical Immunology·William A NeavilleRobert F Lemanske
Dec 10, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hong-biao LiuRhonda R Voskuhl
Mar 6, 2004·Molecular Endocrinology·Véronique BourdeauSylvie Mader
Oct 29, 2004·The Journal of Clinical Endocrinology and Metabolism·R Ravi ShankarJ Howard Pratt
Mar 1, 2006·BMC Immunology·Rebecca LamasonKanneboyina Nagaraju
Apr 25, 2006·Biostatistics·W Evan JohnsonAriel Rabinovic
Jul 21, 2007·Endocrine Reviews·Rainer H Straub
Dec 25, 2007·Gender Medicine·Dirkje S Postma
May 10, 2008·Bioinformatics·Pan DuSimon M Lin
Nov 13, 2008·Nature Reviews. Genetics·Carole OberYoav Gilad
Dec 31, 2008·BMC Bioinformatics·Peter Langfelder, Steve Horvath
Jun 19, 2009·American Journal of Preventive Medicine·Yasmin A AltwaijriDarwin R Labarthe
Jul 16, 2010·Arteriosclerosis, Thrombosis, and Vascular Biology·Jean-François ArnalPierre Gourdy
Sep 15, 2010·Nature Reviews. Genetics·Jeffrey T LeekRafael A Irizarry
Nov 4, 2011·The Journal of Pediatrics·Vicente GilsanzHouchun H Hu
Mar 2, 2012·European Journal of Endocrinology·Kaspar SørensenAnders Juul
Oct 24, 2012·Pediatric Research·Vicente GilsanzShingo Kajimura
Apr 17, 2013·BMC Bioinformatics·Edward Y ChenAvi Ma'ayan
Oct 22, 2013·Genome Biology·Steve Horvath
Mar 29, 2014·BMC Genomics·Yulia A MedvedevaUNKNOWN FANTOM consortium
Jan 22, 2015·Nucleic Acids Research·Matthew E RitchieGordon K Smyth
Oct 17, 2015·American Journal of Respiratory and Critical Care Medicine·Jessie Nicodemus-JohnsonCarole Ober
Nov 27, 2015·American Journal of Physiology. Lung Cellular and Molecular Physiology·Christina DraijerBarbro N Melgert
Dec 5, 2015·Frontiers in Immunology·Aleksander Keselman, Nicola Heller
Feb 8, 2016·The Lancet. Diabetes & Endocrinology·Ana Paula Abreu, Ursula B Kaiser
May 5, 2016·Nucleic Acids Research·Maxim V KuleshovAvi Ma'ayan
May 18, 2016·Current Diabetes Reports·Megan M Kelsey, Philip S Zeitler
Aug 23, 2016·Nature Reviews. Immunology·Sabra L Klein, Katie L Flanagan

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Citations

Dec 18, 2019·PloS One·Klaus RostgaardHenrik Hjalgrim
Jun 4, 2020·Biology of Sex Differences·Katherine E Kight, Margaret M McCarthy
Jun 5, 2020·BMC Genomics·Sarah Rose MooreIan Henry Gotlib
Nov 14, 2018·Future Microbiology·Rose B Joachim, Lester Kobzik
Nov 24, 2018·Clinical Epigenetics·Danielle S BessaAna Claudia Latronico
Jul 6, 2020·Nature Reviews. Endocrinology·Ben Bar-SadehPhilippa Melamed
Feb 16, 2021·Frontiers in Immunology·Rebecca ShepherdBoris Novakovic
Sep 22, 2020·Molecular and Cellular Endocrinology·Dor Shalev, Philippa Melamed
Jul 10, 2021·Pediatric Research·Jennifer Bermick, Matthew Schaller

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Methods Mentioned

BETA
chip
PCA

Software Mentioned

ComBat
IPA
R package lumi
WGCNA
Ingenuity Pathway Analysis
Minfi
SWAN
Enrichr
Ingenuity Pathway Analysis ( IPA )
R

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