Global DNA methylation levels are modulated by mitochondrial DNA variants

Epigenomics
Dina BellizziGiuseppe Passarino

Abstract

In the present study, we investigated whether global DNA methylation levels are affected by mitochondrial DNA (mtDNA) variants, which are known to modulate mitochondrial functions. Global DNA methylation levels were evaluated in peripheral blood DNA collected from adult subjects and in vitro using the DNA of cybrid cells harboring mtDNAs of different haplogroups. In these cells, mRNA expression of genes involved in DNA methylation processes, and ATP and reactive oxygen species levels were also analyzed. The analysis revealed that methylation levels were higher in the subjects carrying the J haplogroup than in non-J carriers. Consistently, cybrids with J haplogroup mtDNA showed higher methylation levels than other cybrids. Interestingly, we observed overexpression of the MAT1A gene and low ATP and ROS levels in J cybrids. Our findings indicate that mtDNA-specific interactions between mitochondria and the nucleus regulate epigenetic changes, possibly by affecting oxidative phosphorylation efficiency.

References

Jan 1, 1987·Nature·R L CannA C Wilson
Aug 27, 1999·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·G De BenedictisC Franceschi
Feb 15, 2001·Nature Genetics·K R JohnsonN Fischel-Ghodsian
Jan 2, 2003·Proceedings of the National Academy of Sciences of the United States of America·Dan MishmarDouglas C Wallace
Jan 13, 2004·Science·Eduardo Ruiz-PesiniDouglas C Wallace
Oct 8, 2004·European Journal of Human Genetics : EJHG·Serena DatoGiovanna De Benedictis
Nov 25, 2004·Experimental Cell Research·Michael V Miceli, S Michal Jazwinski
Sep 17, 2005·Neuroscience Letters·Cristofol Vives-BauzaAntonio L Andreu
May 9, 2006·Trends in Genetics : TIG·Antonio TorroniHans-Jürgen Bandelt
Jul 22, 2006·Biochimica Et Biophysica Acta·Aurelia SantoroClaudio Franceschi
Jul 27, 2006·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Dina BellizziGiovanna De Benedictis
Sep 2, 2006·Human Mutation·Eduardo Ruiz-Pesini, Douglas C Wallace
Jan 16, 2007·Molecular Biology and Evolution·Luísa PereiraVincent Macaulay
Jan 18, 2007·Annual Review of Biochemistry·Michael T Ryan, Nicholas J Hoogenraad
May 10, 2007·The Biochemical Journal·Joanna L ElsonRobert W Taylor
Jun 7, 2007·Journal of Medical Genetics·P F ChinneryM Walker
Sep 8, 2007·Mitochondrion·G CanninoA M Rinaldi
Nov 28, 2007·Journal of Neuroscience Research·Junghee LeeHoon Ryu
May 7, 2008·Cancer Biology & Therapy·Dominic J SmiragliaKeshav K Singh
Jul 19, 2008·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·G RoseG De Benedictis
Aug 19, 2008·Neuroscience Letters·Michelangelo MancusoLuigi Murri
Aug 23, 2008·Cancer Biology & Therapy·Robert K Naviaux
Oct 28, 2008·Mitochondrion·Ana MarcuelloCarmen Díez-Sánchez
Dec 17, 2008·Annals of the New York Academy of Sciences·Elza KhusnutdinovaDouglas C Wallace
May 12, 2009·Free Radical Biology & Medicine·Alicia J KowaltowskiAnibal E Vercesi
Jun 6, 2009·Ageing Research Reviews·Lydia W S Finley, Marcia C Haigis

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Citations

Jan 10, 2014·Human Genetics·Hyang-Min Byun, Andrea A Baccarelli
Sep 8, 2015·Epigenomics·Patrizia D'AquilaDina Bellizzi
Oct 6, 2015·Mitochondrion·Sourav GhoshVinod Scaria
Jan 3, 2013·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Jonci N Wolff, Neil J Gemmell
May 20, 2014·Arthritis & Rheumatology·Francisco J Blanco, Ignacio Rego-Pérez
Jun 24, 2014·Pharmacology & Therapeutics·Anna Sadakierska-ChudyMałgorzata Filip
Dec 20, 2014·European Journal of Clinical Investigation·André FerreiraTeresa Cunha-Oliveira
Feb 26, 2015·Biogerontology·Patrizia D'AquilaGiuseppe Passarino
Nov 20, 2013·Biochimica Et Biophysica Acta·Damian K Dowling
Feb 5, 2015·International Journal of Radiation Biology·Irena Szumiel
May 13, 2015·Human Molecular Genetics·Shari R AtilanoM Cristina Kenney
Jul 22, 2014·Ageing Research Reviews·Andrea LauriMaurizio C Capogrossi
Dec 19, 2012·Maturitas·Patrizia D'AquilaGiuseppe Passarino
Nov 5, 2013·Biochimica Et Biophysica Acta·Justin St John
Feb 1, 2014·Neurocase·Ali Bani-FatemiVincenzo De Luca
Dec 23, 2014·Epigenomics·Matthew DevallKatie Lunnon
Jun 29, 2016·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Alan DiotJoanna Poulton
Jan 25, 2017·Mechanisms of Ageing and Development·Maria Giulia BacaliniDina Bellizzi
Aug 25, 2016·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Salvatore TerrazzinoMarco Krengli
Mar 24, 2017·British Journal of Pharmacology·Thomas KietzmannAgnes Görlach
Feb 2, 2017·The Journal of Clinical Investigation·Ana L MoraMauricio Rojas
Apr 11, 2017·Journal of Cancer Research and Clinical Oncology·Edoardo Errichiello, Tiziana Venesio
Oct 27, 2017·Psychiatric Genetics·Ali Bani-FatemiVincenzo de Luca
Dec 12, 2017·Translational Psychiatry·Gabriel R FriesJoao Quevedo
Nov 2, 2017·Journal of Ophthalmic & Vision Research·Mohammad Riazi-EsfahaniM Cristina Kenney
Jul 17, 2019·Proceedings of the National Academy of Sciences of the United States of America·Jessica L Fetterman, Scott W Ballinger
Nov 14, 2019·Current Pharmaceutical Design·Francesco GuarasciGiuseppe Passarino
Aug 1, 2013·Biomolecular Concepts·Hari Manev, Svetlana Dzitoyeva
Nov 7, 2015·Bioscience Reports·J William O Ballard, Neil A Youngson
Oct 12, 2018·Carcinogenesis·Jialin XiaoRenee Reams
Feb 6, 2020·Frontiers in Genetics·Ignacio Rego-PérezFrancisco J Blanco

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Methods Mentioned

BETA
PCR
blood drawn

Software Mentioned

Cell Quest
SPSS

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