Global DNA methylation was changed by a maternal high-lipid, high-energy diet during gestation and lactation in male adult mice liver

The British Journal of Nutrition
Huan-Ling YuRong Xiao

Abstract

An epigenetic mechanism has been suggested to explain the effects of the maternal diet on the development of disease in offspring. The present study aimed to observe the effects of a maternal high-lipid, high-energy (HLE) diet on the DNA methylation pattern of male offspring in mice. Female C57BL/6J mice were fed an HLE diet during gestation and lactation. The genomic DNA methylations at promoter sites of genes in the liver, mRNA and protein levels of selected genes related to lipid and glucose metabolism were measured by microarray, real-time PCR and Western blot. The results indicated that the percentage of methylated DNA in offspring from dams that were fed an HLE diet was significantly higher than that from dams that were fed a chow diet, and most of these genes were hypermethylated in promoter regions. The nuclear protein content and mRNA levels of hypermethylated genes, such as PPARγ and liver X receptor α (LXRα), were decreased significantly in offspring in the HLE group. The results suggested that the DNA methylation profile in adult offspring livers was changed by the maternal HLE diet during gestation and lactation.

References

Sep 1, 1989·Journal of Epidemiology and Community Health·D J BarkerC M Law
Oct 28, 1999·The American Journal of Clinical Nutrition·A C RavelliO P Bleker
Jun 27, 2000·The Journal of Nutrition·W D ReesR M Palmer
Jul 14, 2000·American Journal of Physiology. Endocrinology and Metabolism·M H VickersP D Gluckman
Nov 4, 2000·The American Journal of Clinical Nutrition·T J RoseboomO P Bleker
Jul 26, 2005·Trends in Cardiovascular Medicine·Yau-Sheng Tsai, Nobuyo Maeda
Aug 30, 2005·Biochemical and Biophysical Research Communications·Mitsutaka InoueToshikatsu Okumura
Feb 14, 2006·Clinical & Experimental Metastasis·Haiyan YangKent W Hunter
May 25, 2007·Nature·Adrian Bird
Jan 30, 2008·Basic & Clinical Pharmacology & Toxicology·I Caroline McMillenJanna L Morrison
Nov 6, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Esther M E van StratenTorsten Plösch
Nov 16, 2010·Nutrition·Analía Lorena TomatCristina Teresa Arranz
May 7, 2011·Journal of Hypertension·Yanping LiGuansheng Ma
Jun 22, 2013·Clinical Obstetrics and Gynecology·Amber Osborne-MajnikRobert H Lane
Jul 23, 2013·Biochimica Et Biophysica Acta·Lyda WilliamsMaureen J Charron

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Citations

May 18, 2016·The Journal of Nutritional Biochemistry·Fei JiaoZhonghai Yan
May 14, 2016·Epigenetics : Official Journal of the DNA Methylation Society·Berthold HocherElke Schaeffeler
Jul 24, 2018·Molecular Nutrition & Food Research·Stephanie AndraosMartin Kussmann
Dec 19, 2018·International Journal of Molecular Sciences·Fatma Zehra KadayifciYuan-Xiang Pan
Apr 14, 2016·Current Opinion in Lipidology·Martin P BogsrudKirsten B Holven
Sep 8, 2020·Expert Review of Gastroenterology & Hepatology·Letícia F RamosKaren C M Moraes
Jul 8, 2017·International Journal of Molecular Sciences·Stephanie M KereliukVernon W Dolinsky
Jun 5, 2020·Cellular and Molecular Life Sciences : CMLS·Efthimia R Christoforou, Amanda N Sferruzzi-Perri
Aug 6, 2019·Frontiers in Genetics·Cristina-Mariana NiculiteMihail Eugen Hinescu
Dec 19, 2020·Frontiers in Endocrinology·Maria Grazia DalfràAnnunziata Lapolla
Mar 7, 2021·Nutrients·Nathalie AcevedoBetty C A M van Esch

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