Global ECG Measures and Cardiac Structure and Function: The ARIC Study (Atherosclerosis Risk in Communities)

Circulation. Arrhythmia and Electrophysiology
Tor Biering-SørensenLarisa G Tereshchenko

Abstract

Electric excitation initiates myocardial mechanical contraction and coordinates myocardial pumping. We hypothesized that ECG global electric heterogeneity (GEH) and its longitudinal changes are associated with cardiac structure and function. Participants from the ARIC study (Atherosclerosis Risk in Communities) (N=5114; 58% female; 22% blacks) with resting 12-lead ECGs (visits 1-5) and echocardiographic assessment of left ventricular (LV) ejection fraction, LV global longitudinal strain, LV mass index, LV end-diastolic volume index, and LV end-systolic volume index at visit 5 were included. Longitudinal analysis included ARIC participants (N=14 609) with measured GEH at visits 1 to 4. GEH was quantified by spatial ventricular gradient, QRS-T angle, and sum absolute QRS-T integral. Cross-sectional and longitudinal regressions were adjusted for manifest and subclinical cardiovascular disease. Having 4 abnormal GEH parameters was associated with a 6.4% (95% confidence interval, 5.5-7.3) LV ejection fraction decline, a 24.2 g/m2 (95% confidence interval, 21.5-26.9) increase in LV mass index, a 10.3 mL/m2 (95% confidence interval, 8.9-11.7) increase in LV end-diastolic volume index, and a 7.8 mL/m2 (95% confidence interval, 6.9-8.6)...Continue Reading

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Citations

Apr 15, 2018·Circulation. Arrhythmia and Electrophysiology·Jonathan W WaksLarisa G Tereshchenko
Apr 5, 2020·Heart and Vessels·Lok-Yee LauYiu-Fai Cheung
May 29, 2021·European Heart Journal. Digital Health·James D PollardLarisa G Tereshchenko
Dec 22, 2020·Terapevticheskiĭ arkhiv·E V BlinovaE S Yurasova

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