Global effects of catecholamines on Actinobacillus pleuropneumoniae gene expression.

PloS One
Lu LiRui Zhou

Abstract

Bacteria can use mammalian hormones to modulate pathogenic processes that play essential roles in disease development. Actinobacillus pleuropneumoniae is an important porcine respiratory pathogen causing great economic losses in the pig industry globally. Stress is known to contribute to the outcome of A. pleuropneumoniae infection. To test whether A. pleuropneumoniae could respond to stress hormone catecholamines, gene expression profiles after epinephrine (Epi) and norepinephrine (NE) treatment were compared with those from untreated bacteria. The microarray results showed that 158 and 105 genes were differentially expressed in the presence of Epi and NE, respectively. These genes were assigned to various functional categories including many virulence factors. Only 18 genes were regulated by both hormones. These genes included apxIA (the ApxI toxin structural gene), pgaB (involved in biofilm formation), APL_0443 (an autotransporter adhesin) and genes encoding potential hormone receptors such as tyrP2, the ygiY-ygiX (qseC-qseB) operon and narQ-narP (involved in nitrate metabolism). Further investigations demonstrated that cytotoxic activity was enhanced by Epi but repressed by NE in accordance with apxIA gene expression change...Continue Reading

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Citations

Dec 13, 2012·Molecular Microbiology·Michail H KaravolosC M Anjam Khan
Apr 16, 2015·Microbiology·Christopher F HarrisonHubert Hilbi
Nov 8, 2017·Animal Health Research Reviews·Skander HathroubiMario Jacques
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May 27, 2016·Microbiology Spectrum·Mark Lyte

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Datasets Mentioned

BETA
CP000569
GSE25516

Methods Mentioned

BETA
Feature Extraction
ELISA

Software Mentioned

Feature Extraction
TM4

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