Global epidemiology of pediatric severe sepsis: the sepsis prevalence, outcomes, and therapies study

American Journal of Respiratory and Critical Care Medicine
Scott L WeissSepsis Prevalence, Outcomes, and Therapies (SPROUT) Study Investigators and Pediatric Acute Lung Injury and Sepsis Investiga

Abstract

Limited data exist about the international burden of severe sepsis in critically ill children. To characterize the global prevalence, therapies, and outcomes of severe sepsis in pediatric intensive care units to better inform interventional trials. A point prevalence study was conducted on 5 days throughout 2013-2014 at 128 sites in 26 countries. Patients younger than 18 years of age with severe sepsis as defined by consensus criteria were included. Outcomes were severe sepsis point prevalence, therapies used, new or progressive multiorgan dysfunction, ventilator- and vasoactive-free days at Day 28, functional status, and mortality. Of 6,925 patients screened, 569 had severe sepsis (prevalence, 8.2%; 95% confidence interval, 7.6-8.9%). The patients' median age was 3.0 (interquartile range [IQR], 0.7-11.0) years. The most frequent sites of infection were respiratory (40%) and bloodstream (19%). Common therapies included mechanical ventilation (74% of patients), vasoactive infusions (55%), and corticosteroids (45%). Hospital mortality was 25% and did not differ by age or between developed and resource-limited countries. Median ventilator-free days were 16 (IQR, 0-25), and vasoactive-free days were 23 (IQR, 12-28). Sixty-seven per...Continue Reading

Associated Clinical Trials

References

Jul 1, 1992·The Journal of Pediatrics·D H Fiser
Dec 1, 1993·American Journal of Epidemiology·G Maldonado, S Greenland
Nov 16, 2002·American Journal of Respiratory and Critical Care Medicine·R Scott WatsonDerek C Angus
Jul 2, 2003·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Martha C KutkoBruce M Greenwald
Jan 8, 2005·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Brahm GoldsteinUNKNOWN International Consensus Conference on Pediatric Sepsis
Feb 5, 2005·Seminars in Fetal & Neonatal Medicine·Shi Wu WenMark Walker
Apr 29, 2005·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Barry P MarkovitzJerry Zimmerman
Apr 29, 2005·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Martha A Q Curley, Jerry J Zimmerman
Jan 21, 2006·Critical Care Medicine·Jean-Louis VincentUNKNOWN Sepsis Occurrence in Acutely Ill Patients Investigators
Mar 14, 2007·Lancet·Simon NadelUNKNOWN REsearching severe Sepsis and Organ dysfunction in children: a gLobal perspective (RESOLVE) study group
Mar 14, 2008·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J C MageeB L Shneider
May 27, 2008·Intensive Care Medicine·Andrea WolflerUNKNOWN Italian Pediatric Sepsis Study (SISPe) group
Dec 6, 2008·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·François ProulxJacques Lacroix
Mar 4, 2009·Pediatrics·Angela S CzajaAvery B Nathens
Jul 18, 2009·American Journal of Respiratory and Critical Care Medicine·Karen ChoongUNKNOWN Canadian Critical Care Trials Group
Dec 3, 2009·JAMA : the Journal of the American Medical Association·Jean-Louis VincentUNKNOWN EPIC II Group of Investigators
Nov 9, 2010·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Oliver KaramUNKNOWN PALISI Network
Nov 26, 2010·Chemotherapy·Anjali N Kunz, Itzhak Brook
Dec 15, 2010·Intensive Care Medicine·Mark W HallJoseph A Carcillo
May 28, 2011·The New England Journal of Medicine·Kathryn MaitlandUNKNOWN FEAST Trial Group
Mar 31, 2012·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Juan C Jaramillo-BustamanteJosé Bareño-Silva
Mar 31, 2012·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Scott L WeissDenise M Goodman
Apr 25, 2012·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·C GudiolJ Carratalà
Jul 4, 2012·Pediatrics·Raina PaulElliot Melendez
Oct 3, 2012·Critical Care : the Official Journal of the Critical Care Forum·Hector R WongChristopher J Lindsell
Jul 19, 2013·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Lahn StraneyUNKNOWN ANZICS Paediatric Study Group and the Paediatric Intensive Care Audit Network
Jul 31, 2013·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Mary E HartmanR Scott Watson
Oct 11, 2013·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Reid W D FarrisJerry J Zimmerman
Mar 19, 2014·JAMA : the Journal of the American Medical Association·Kirsi-Maija KaukonenRinaldo Bellomo
Apr 23, 2014·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Scott L WeissUNKNOWN Pediatric Acute Lung Injury and Sepsis Investigators Network and Australia and New Zealand Intensive Care Society Investigat
Aug 28, 2014·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Fran BalamuthElizabeth R Alpern
Sep 17, 2014·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Amanda RuthKiran B Hebbar
Sep 27, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Chanu RheeUNKNOWN Centers for Disease Control and Prevention Epicenters Program
Nov 12, 2014·PloS One·Sarah J AtkinsonHector R Wong

❮ Previous
Next ❯

Citations

Dec 17, 2015·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Sarah B KliegerSusan E Coffin
Sep 29, 2015·The Journal of Pediatrics·Ayse Akcan ArikanAndrea T Cruz
Feb 10, 2016·The Journal of Pharmacology and Experimental Therapeutics·Clark R SimsPhilip R Mayeux
Sep 17, 2015·Critical Care : the Official Journal of the Critical Care Forum·Scott L WeissUNKNOWN SPROUT Study Investigators and Pediatric Acute Lung Injury and Sepsis Investigators Network
Jun 19, 2015·Indian Journal of Pediatrics·Javed Ismail, Jhuma Sankar
May 6, 2016·Journal of the Pediatric Infectious Diseases Society·Kevin J DownesUNKNOWN Centers for Disease Control and Prevention Epicenters Program
Oct 30, 2016·Jornal de pediatria·Prasad Devarajan, Rajit K Basu
Oct 26, 2016·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·T XiaY Tang
Apr 5, 2017·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Sunit C Singhi, Naveen Sankhyan
Mar 4, 2017·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Scott L Weiss
Jan 19, 2017·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Kusum MenonKaren Choong
Apr 14, 2017·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Kusum MenonUNKNOWN Canadian Critical Care Trials Group
Jan 7, 2017·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Nobuaki ShimeSatoshi Nakagawa
Mar 21, 2017·Intensive Care Medicine·Mark J PetersJacques Lacroix
Mar 2, 2017·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Robert F Tamburro, Tammara L Jenkins
Mar 2, 2017·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·R Scott WatsonFolafoluwa O Odetola
Mar 2, 2017·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Katri V Typpo, Jacques R Lacroix
Mar 2, 2017·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Allan DoctorKatri Typpo
Feb 22, 2017·Intensive Care Medicine·Luregn J SchlapbachUNKNOWN Australian & New Zealand Intensive Care Society (ANZICS) Centre for Outcomes & Resource Evaluation (CORE) and Australian & N
Jan 7, 2017·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Jennifer K Workman, Gitte Y Larsen
Jun 26, 2017·The Journal of Infection·Sagar Dugani, Niranjan Kissoon
Dec 6, 2017·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Elizabeth J Beckman
Dec 8, 2017·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Elina KyöstiTero Ala-Kokko
May 27, 2017·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Scott L WeissJennifer Muszynski
Jun 29, 2017·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Blake NicholsVijay Srinivasan
Oct 5, 2017·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Teresa Kortz, Niranjan Kissoon
Aug 11, 2017·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Srinivas Murthy
Sep 20, 2017·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Robert B LindellUNKNOWN Sepsis PRevalence, OUtcomes, and Therapies Study Investigators and the Pediatric Acute Lung Injury and Sepsis Investigators
Aug 18, 2017·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Kusum MenonKaren Choong
Nov 8, 2017·Critical Care Medicine·Jeffrey J CiesArun Chopra
Sep 2, 2017·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Derek S Wheeler
Jan 26, 2018·Critical Care Medicine·Jerry J Zimmerman
Feb 3, 2018·Surgical Infections·Bryanna M EmrKevin P Mollen
Jan 30, 2018·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Kelly N MichelsonUNKNOWN Sepsis Prevalence, Outcomes, and Therapy (SPROUT) Study Investigators and Pediatric Acute Lung Injury and Sepsis Investigato
Nov 25, 2016·American Journal of Physiology. Heart and Circulatory Physiology·Stephen W StandageAaron K Olson
Aug 30, 2017·SLAS Technology·Eranda M K Kurundu HewageNeal J Thomas

❮ Previous
Next ❯

Related Concepts

Related Feeds

American Thoracic Association Journals

Discover the latest respiratory research published by the journals from the American Thoracic Society.

Related Papers

American Journal of Respiratory and Critical Care Medicine
Bertrand SouweineJean-François Timsit
Indian Journal of Critical Care Medicine : Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine
Harsha V PatilR D Kulkarni
Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
Susan L. BrattonMichael D. Cabana
© 2022 Meta ULC. All rights reserved