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Global Epistasis Makes Adaptation Predictable Despite Sequence-Level Stochasticity

bioRxiv

Jan 13, 2014

Sergey KryazhimskiyMichael M Desai

Abstract

Epistasis can make adaptation highly unpredictable, rendering evolutionary trajectories contingent on the chance effects of initial mutations. We used experimental evolution in Saccharomyces cerevisiae to quantify this effect, finding dramatic differences in adaptability between 64 clos...read more

Mentioned in this Paper

Clone
Sequencing
Orientation (spatial)
Physiological Processes
Saccharomyces cerevisiae
Adaptation
Patterns
Clone Cells
Research Study
Epistasis, Genetic
9
39
Paper Details
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Global Epistasis Makes Adaptation Predictable Despite Sequence-Level Stochasticity

bioRxiv

Jan 13, 2014

Sergey KryazhimskiyMichael M Desai

PMID: 990001784

DOI: 10.1101/001784

Abstract

Epistasis can make adaptation highly unpredictable, rendering evolutionary trajectories contingent on the chance effects of initial mutations. We used experimental evolution in Saccharomyces cerevisiae to quantify this effect, finding dramatic differences in adaptability between 64 clos...read more

Mentioned in this Paper

Clone
Sequencing
Orientation (spatial)
Physiological Processes
Saccharomyces cerevisiae
Adaptation
Patterns
Clone Cells
Research Study
Epistasis, Genetic
9
39
Paper Details
References
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  • Citations
  • finger pointing at paper

    References currently unavailable

    We're still populating references for this paper, please check back later.
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