Global experience and perspective on anonymous nondirected live donation in living donor liver transplantation.

Clinical Transplantation
Muhammad H RazaJuliet Emamaullee

Abstract

Anonymous nondirected living liver donation (ANLLD), sometimes referred to as "altruistic" donation, occurs when a biologically unrelated person comes forward to donate a portion of his/her liver to a transplant candidate who is unknown to the donor. Here, we explore the current status of ANLLD with special consideration of published reports; US experience; impact on donor psychosocial outcomes; barriers to donation; and current global trends with respect to ethical considerations. Between 1998 and 2019, 105 anonymous nondirected living liver donor (ND-LLD) transplants have been documented in the US Scientific Registry of Transplant Recipients. Sixteen donors (15%) were reported to experience a postoperative complication. Currently, 89 donors remain alive (85%), 16 (15%) have unknown status, and none are confirmed deceased. Although there are only a handful of case series, these data suggest that ANLLD is a feasible option. While there are no liver-specific data, studies involving anonymous nondirected kidney donors suggest that anonymous donation does not adversely impact psychosocial outcomes in donors or recipients. There are substantial financial burdens and ethical considerations related to ANLLD. Further studies are requi...Continue Reading

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Citations

Aug 3, 2020·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Muhammad H RazaJuliet Emamaullee
Jun 17, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Philip E Castle
Nov 11, 2020·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Hillary J BraunJohn P Roberts
Feb 24, 2021·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Thomas G CotterMichael Charlton
Dec 11, 2020·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Arianna BarbettaJuliet Emamaullee
Jun 27, 2021·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Alyson KaplanRobert S Brown
May 29, 2021·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Dor YoeliElizabeth A Pomfret
Jun 25, 2021·Transplant International : Official Journal of the European Society for Organ Transplantation·Juliet EmamaulleeYuri Genyk

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