Global gene expression in larval zebrafish (Danio rerio) exposed to selective serotonin reuptake inhibitors (fluoxetine and sertraline) reveals unique expression profiles and potential biomarkers of exposure

Environmental Pollution
June-Woo ParkGary S Sayler

Abstract

Larval zebrafish (Danio rerio) were exposed (96 h) to selective serotonin reuptake inhibitors (SSRIs) fluoxetine and sertraline and changes in transcriptomes analyzed by Affymetrix GeneChip Zebrafish Array were evaluated to enhance understanding of biochemical pathways and differences between these SSRIs. The number of genes differentially expressed after fluoxetine exposure was 288 at 25 μg/L and 131 at 250 μg/L; and after sertraline exposure was 33 at 25 μg/L and 52 at 250 μg/L. Same five genes were differentially regulated in both SSRIs indicating shared molecular pathways. Among these, the gene coding for FK506 binding protein 5, annotated to stress response regulation, was highly down-regulated in all treatments (results confirmed by qRT-PCR). Gene ontology analysis indicated at the gene expression level that regulation of stress response and cholinesterase activities were influenced by these SSRIs, and suggested that changes in transcription of these genes could be used as biomarkers of SSRI exposure.

References

Dec 1, 1984·The Journal of Clinical Endocrinology and Metabolism·F PetragliaA R Genazzani
Jan 1, 1993·Brain Research. Brain Research Reviews·F Chaouloff
Mar 19, 1999·Brain, Behavior, and Immunity·R Mössner, K P Lesch
May 16, 2002·Biochimica Et Biophysica Acta·Tatiane C MüllerMaria R C Schetinger
Feb 26, 2003·European Journal of Pharmacology·Gonzalo A Carrasco, Louis D Van de Kar
Apr 15, 2003·Toxicology Letters·Bryan W BrooksThomas W La Point
Dec 10, 2003·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Haruhiko KawanoMasahiro Sakai
Jan 10, 2004·Environmental Toxicology and Chemistry·Chris D MetcalfeJohn Struger
Jul 16, 2004·Archives of Environmental Contamination and Toxicology·Christy M ForanDuane B Huggett
Sep 24, 2004·Environmental Toxicology and Chemistry·Theodore B HenryMarsha C Black
Jan 26, 2005·Toxicology and Applied Pharmacology·Edward J Calabrese, Robyn Blain
Feb 24, 2006·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·June-Woo ParkJohn P Giesy
May 17, 2006·Toxicology and Applied Pharmacology·Hiroyoshi ToyoshibaChristopher J Portier
Feb 3, 2007·Environmental Toxicology and Chemistry·Anne Munch ChristensenAnders Baun
Sep 4, 2007·Archives of Environmental Contamination and Toxicology·T B Henry, M C Black
Mar 8, 2008·Critical Reviews in Toxicology·N Kreke, D R Dietrich
Jul 29, 2008·Molecular and Cellular Endocrinology·Jason T PopeskuVance L Trudeau
Sep 4, 2008·Physiological Genomics·Jan A MennigenVance L Trudeau
May 16, 2009·Aquatic Toxicology·Michael B MorandoM Danielle McDonald
May 26, 2009·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·T B HenryG S Sayler
Jul 1, 2009·Pharmacology & Therapeutics·Sonja Horstmann, Elisabeth B Binder
Aug 12, 2009·Environmental Toxicology and Chemistry·Theodore W ValentiBryan W Brooks
Oct 10, 2009·Chemosphere·Vânia Calisto, Valdemar I Esteves
Sep 8, 2010·Environmental Toxicology and Chemistry·Chris D MetcalfeDavid M Andrews
Oct 5, 2010·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·M Danielle McDonaldKatherine A Sloman

❮ Previous
Next ❯

Citations

Jul 24, 2014·PloS One·Murilo Sander de AbreuLeonardo José Gil Barcellos
Jan 9, 2014·Briefings in Functional Genomics·Tim D WilliamsJ Kevin Chipman
Sep 14, 2014·Aquatic Toxicology·Aurélie P RodriguesLaura Guimarães
Sep 16, 2015·Aquatic Toxicology·Allan V KalueffUNKNOWN International Zebrafish Neuroscience Research Consortium ZNRC
Sep 26, 2015·Behavioural Brain Research·Ana Cristina V V GiacominiLeonardo J G Barcellos
Sep 2, 2015·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Murilo S AbreuLeonardo J G Barcellos
Apr 17, 2015·Toxicological Sciences : an Official Journal of the Society of Toxicology·Julieta M Panzica-KellyKaren A Augustine-Rauch
Sep 18, 2014·Archives of Environmental Contamination and Toxicology·L A MaranhoM L Martín-Díaz
Nov 28, 2002·Gastroenterology·Douglas A DrossmanWilliam E Whitehead
Mar 23, 2017·Toxicological Sciences : an Official Journal of the Society of Toxicology·Andreas SchüttlerWibke Busch
May 15, 2018·Environmental Technology·Przemysław DrzewiczGrzegorz Nałęcz-Jawecki
Oct 30, 2019·Environmental Science and Pollution Research International·Marco ParoliniLuca Del Giacco
Aug 29, 2021·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Carolina CostaRalph Urbatzka

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.