PMID: 16636312Apr 26, 2006Paper

Global gene expression in mouse vaginae exposed to diethylstilbestrol at different ages

Experimental Biology and Medicine
Atsuko SuzukiTaisen Iguchi

Abstract

Estrogens regulate proliferation and differentiation of cells in target organs such as the female reproductive tract. In mature mice, estrogens stimulate cell proliferation, whereas ovariectomy results in atrophy of the female reproductive tract. In contrast, perinatal exposure to estrogens, including diethylstilbestrol (DES), induces persistent, ovary-independent vaginal stratification and cervico-vaginal tumors later in life. These effects are due to altered cell fate following DES exposure during a critical developmental period. The detailed mechanisms underlying the reversible and irreversible cell proliferation in vaginae induced by DES at different ages has not been clarified. Therefore, we examined differences in gene expression pattern using DNA microarray analysis in mouse vaginae 6 hrs after a single injection of 2 mug DES per gram of body weight, and proliferation of vaginal epithelial and stromal cells 24 hrs after the injection at postnatal days (PNDs) 0, 5, 20, and 70. After DES stimulation, vaginal epithelial and stromal cells showed cell proliferation at PNDs 20 and 70, and at PNDs 0 and 5, respectively. DNA microarray analysis exhibited 54 DES-induced genes and 9 DES-repressed genes in vaginae at PND 0, whereas...Continue Reading

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Citations

Feb 6, 2008·International Journal of Andrology·T IguchiB Blumberg
Feb 19, 2010·Toxicology Mechanisms and Methods·Yan HongWeiquan Liu
Aug 2, 2012·The Journal of Veterinary Medical Science·Takeshi NakamuraYasuhiko Ohta
Dec 3, 2016·Proceedings of the National Academy of Sciences of the United States of America·Tadaaki NakajimaTomomi Sato
Jan 5, 2018·The Journal of Endocrinology·Yanwen JiangXu Zhou
Nov 16, 2020·Differentiation; Research in Biological Diversity·Taisen IguchiNoboru Takasugi

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