Global hepatic gene expression in rainbow trout exposed to sewage effluents: a comparison of different sewage treatment technologies

The Science of the Total Environment
Filip CuklevD G J Larsson

Abstract

Effluents from sewage treatment plants contain a mixture of micropollutants with the potential of harming aquatic organisms. Thus, addition of advanced treatment techniques to complement existing conventional methods has been proposed. Some of the advanced techniques could, however, potentially produce additional compounds affecting exposed organisms by unknown modes of action. In the present study the aim was to improve our understanding of how exposure to different sewage effluents affects fish. This was achieved by explorative microarray and quantitative PCR analyses of hepatic gene expression, as well as relative organ sizes of rainbow trout exposed to different sewage effluents (conventionally treated, granular activated carbon, ozonation (5 or 15 mg/L), 5 mg/L ozone plus a moving bed biofilm reactor, or UV-light treatment in combination with hydrogen peroxide). Exposure to the conventionally treated effluent caused a significant increase in liver and heart somatic indexes, an effect removed by all other treatments. Genes connected to xenobiotic metabolism, including cytochrome p450 1A, were differentially expressed in the fish exposed to the conventionally treated effluents, though only effluent treatment with granular ac...Continue Reading

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Citations

Jun 23, 2012·Journal of Hazardous Materials·Filip CuklevD G Joakim Larsson
Jun 26, 2013·Aquatic Toxicology·Doris E Vidal-DorschGary Hardiman
Apr 2, 2015·Water Research·Yael Schindler WildhaberUrs von Gunten
May 24, 2019·Environmental Science & Technology·Johannes VölkerMartin Wagner

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