Global In-Silico Scenario of tRNA Genes and Their Organization in Virus Genomes

Viruses
Sergio M Morgado, Ana C P Vicente

Abstract

Viruses are known to be highly dependent on the host translation machinery for their protein synthesis. However, tRNA genes are occasionally identified in such organisms, and in addition, few of them harbor tRNA gene clusters comprising dozens of genes. Recently, tRNA gene clusters have been shown to occur among the three domains of life. In such a scenario, the viruses could play a role in the dispersion of such structures among these organisms. Thus, in order to reveal the prevalence of tRNA genes as well as tRNA gene clusters in viruses, we performed an unbiased large-scale genome survey. Interestingly, tRNA genes were predicted in ssDNA (single-stranded DNA) and ssRNA (single-stranded RNA) viruses as well in many other dsDNA viruses of families from Caudovirales order. In the latter group, tRNA gene clusters composed of 15 to 37 tRNA genes were characterized, mainly in bacteriophages, enlarging the occurrence of such structures within viruses. These bacteriophages were from hosts that encompass five phyla and 34 genera. This in-silico study presents the current global scenario of tRNA genes and their organization in virus genomes, contributing and opening questions to be explored in further studies concerning the role of th...Continue Reading

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Citations

Oct 22, 2020·Viruses·Garry A DuncanJames L Van Van Etten
Feb 24, 2021·Microbial Genomics·Sergio Mascarenhas Morgado, Ana Carolina Paulo Vicente
Mar 18, 2021·Cell Reports·Xavier Hernandez-AliasLuis Serrano
Apr 3, 2021·Frontiers in Molecular Biosciences·Ricardo EhrlichMónica Marín
Aug 12, 2021·Nucleic Acids Research·Javier Santamaría-GómezIgnacio Luque
Oct 10, 2021·BMC Biology·Andrzej ZielezinskiWojciech M Karlowski
Dec 7, 2021·Frontiers in Cellular and Infection Microbiology·Antonio J Martín-Galiano, Ernesto García

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Software Mentioned

CodonW
_ HOMOLOGUES
SE
Kraken
RStudio
BLAST
ModelGenerator
R language
Prokka
tRNAscan

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