Global Investigation of Immune Repertoire Suggests Kawasaki Disease Has Infectious Cause

Circulation Journal : Official Journal of the Japanese Circulation Society
Ho-Chang KuoLien-Hung Huang

Abstract

Kawasaki disease (KD) severely threatens young children's health worldwide. The pathogenic mechanism of KD has not yet been solved, so there is still debate over whether KD is an infectious disease or an autoimmune disease.Methods and Results:To solve this problem, an immune repertoire analysis of KD was conducted. We collected blood cell RNA samples and prepared them into amplicons with iRepertoire kits. The amplicons were sequenced and analyzed with the iRepertoire pipeline. We first identified KD-specific VJ and VDJ forms that had the potential to serve as biomarkers of KD. In addition, the KD-specific VDJ forms were contributed mostly by immunoglobulin G. The D50 value analysis showed that B-cell diversity in KD is decreased, suggesting unique immunoglobulins are produced in KD. Moreover, V, D and J segment usage in IgA, IgG and IgM was consistent with previous KD studies. Further comparison showed no difference in CDR3 peptide length between KD and fever controls (subjects with fever but not diagnosed as KD), indicting KD had B-cell selection phenomenon that has a non-autoimmune pattern. The comparison of amino acid usage of the CDR3 region demonstrated a preference for hydrophilic amino acids in KD. The results of D50 val...Continue Reading

References

Jun 1, 1992·Archives of Disease in Childhood·S FurukawaK Yabuta
Mar 28, 1995·Proceedings of the National Academy of Sciences of the United States of America·S M BarbasD R Burton
Feb 1, 1997·International Archives of Allergy and Immunology·J HiraoT Ichimura
Jan 6, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·A H RowleyS C Baker
Sep 19, 2001·The Journal of Clinical Investigation·E MeffreC Schiff
Jan 5, 2002·Arthritis and Rheumatism·T Dörner, P E Lipsky
May 2, 2002·Pediatrics International : Official Journal of the Japan Pediatric Society·Seiichiro TakeshitaIsao Sekine
Aug 16, 2003·Science·Hedda WardemannMichel C Nussenzweig
Aug 11, 2004·Lancet·Jane C Burns, Mary P Glodé
Dec 21, 2004·Nucleic Acids Research·Marie-Paule LefrancGérard Lefranc
Dec 8, 2007·The Journal of Clinical Investigation·Renee C TschumperDiane F Jelinek
Jan 30, 2010·Expert Review of Anti-infective Therapy·Anne H Rowley, Stanford T Shulman
May 21, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Marian L TurnerPhilip D Hodgkin
Nov 21, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Janet Stavnezer, Carol E Schrader
Oct 27, 2015·BMC Musculoskeletal Disorders·Yan DingLei Zhao
Jul 28, 2016·The Journal of Allergy and Clinical Immunology·Ho-Chang KuoSung-Chou Li
Sep 4, 2016·Expert Review of Clinical Immunology·Shreya Agarwal, Devendra K Agrawal
Mar 31, 2017·Circulation·Brian W McCrindleUNKNOWN American Heart Association Rheumatic Fever, Endocarditis, and Kawasaki Disease Committee of the Council on Cardiovascular Di
Jan 9, 2019·Frontiers in Pediatrics·Anne H Rowley, Stanford T Shulman
Feb 26, 2019·Frontiers in Pediatrics·Satoru Nagata

❮ Previous
Next ❯

Citations

Feb 20, 2020·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Ling-Sai ChangHo-Chang Kuo
Jan 26, 2021·Frontiers in Pediatrics·Po-Yu HuangHo-Chang Kuo
Jun 18, 2021·Frontiers in Microbiology·Han SunZhao-Hui Tong

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Related Papers

Clinical Immunology : the Official Journal of the Clinical Immunology Society
Manish RameshCharlotte Cunningham-Rundles
MCN. the American Journal of Maternal Child Nursing
S Sealy
© 2021 Meta ULC. All rights reserved