Global longitudinal strain and long-term outcomes in asymptomatic extracardiac sarcoid patients with no apparent cardiovascular disease

Echocardiography
Ioannis FelekosDimitris Tousoulis

Abstract

Global longitudinal strain (GLS) is increasingly accepted as a predictor of mortality in various clinical settings. This study tested the hypothesis that GLS is associated with increased event rate in patients with extracardiac sarcoidosis, who have no overt symptoms of cardiovascular disease and preserved ejection fraction (EF). We retrospectively studied 117 patients with extracardiac sarcoidosis and 45 age- and sex-matched controls, who underwent comprehensive echocardiographic study, while GLS was measured by an offline speckle tracking algorithm. Patients who had signs and symptoms of cardiovascular disease at the time of the examination were excluded from the study. Patients were followed for an average of 57.1 months. Primary endpoint was defined as a composite endpoint of heart failure-related hospitalizations, need for device therapy, arrhythmias, and all-cause mortality. The age of patients was 42 ± 6 years old (43 men). Events were recorded in 10 patients (8.5%). Tissue Doppler revealed E/Em 7.9 ± 3.5, while EF was 54.2 ± 3.5%. Global longitudinal strain was 14.4 ± 3%, and a cutoff value ≤-13.6% for GLS was considered more associated with adverse outcomes (AUC 0.84). After adjustment for multiple potential confounder...Continue Reading

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Citations

Aug 8, 2018·Current Treatment Options in Cardiovascular Medicine·Yan YatsynovichNathaniel Dittoe
Jul 28, 2019·Current Cardiology Reviews·Francis J HaLynne Williams
Sep 28, 2018·Current Cardiology Reports·Reto KurmannRekha Mankad
Apr 25, 2020·Progress in Cardiovascular Diseases·Jan-Peter SmedemaHarry J G M Crijns
Jun 30, 2021·Heart Failure Reviews·Tanushree AgrawalMouaz Al-Mallah

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