Global longitudinal strain is not impaired in type 1 diabetes patients without albuminuria: the Thousand & 1 study

JACC. Cardiovascular Imaging
Magnus T JensenJan S Jensen

Abstract

The purpose of this study was to investigate if systolic myocardial function is reduced in all patients with type 1 diabetes (T1DM) or only in patients with albuminuria. Heart failure is a common cause of mortality in T1DM, and a specific diabetic cardiomyopathy has been suggested. It is not known whether myocardial dysfunction is a feature of T1DM per se or primarily associated with diabetes with albuminuria. This cross-sectional study compared 1,065 T1DM patients without known heart disease from the outpatient clinic at the Steno Diabetes Center with 198 healthy control subjects. Conventional echocardiography and global longitudinal strain (GLS) by 2-dimensional speckle-tracking echocardiography was performed and analyzed in relation to normoalbuminuria (n = 739), microalbuminuria (n = 223), and macroalbuminuria (n = 103). Data were analyzed in univariable and multivariable linear regression models adjusted for confounding factors including conventional risk factors, medication, and systolic and diastolic dysfunction. Investigators were blinded to degree of albuminuria. Mean age was 49.5 years, 52% men, mean glycated hemoglobin 8.2% (66 mmol/mol), mean body mass index 25.5 kg/m(2), and mean diabetes duration 26.1 years. In un...Continue Reading

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Citations

Jan 23, 2016·The International Journal of Cardiovascular Imaging·Tor Biering-SørensenMagnus Thorsten Jensen
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Dec 27, 2016·JACC. Cardiovascular Imaging·Scott D Solomon, Tor Biering-Sørensen
May 22, 2016·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Peter Godsk JørgensenJan S Jensen
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