Global low-frequency motions in protein allostery: CAP as a model system

Biophysics Reviews
Philip D TownsendMartin J Cann

Abstract

Allostery is a fundamental process by which ligand binding to a protein alters its activity at a distant site. There is considerable evidence that allosteric cooperativity can be communicated by the modulation of protein dynamics without conformational change. The Catabolite Activator Protein (CAP) of Escherichia coli is an important experimental exemplar for entropically driven allostery. Here we discuss recent experimentally supported theoretical analysis that highlights the role of global low-frequency dynamics in allostery in CAP and identify how allostery arises as a natural consequence of changes in global low-frequency protein fluctuations on ligand binding.

References

Jan 1, 1984·European Biophysics Journal : EBJ·A Cooper, D T Dryden
Jun 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·N GoT Nishikawa
Nov 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·B Brooks, M Karplus
Apr 5, 2001·Protein Engineering·F Tama, Y H Sanejouand
Sep 10, 2003·Journal of Molecular Biology·H ValadiéC Etchebest
May 1, 1965·Journal of Molecular Biology·J MONODJ P CHANGEUX
Sep 28, 2004·Physical Review Letters·Rhoda J Hawkins, Tom C B McLeish
Apr 12, 2006·Physical Review Letters·S Nicolay, Y-H Sanejouand
Jun 27, 2006·Biophysical Journal·Rhoda J Hawkins, Tom C B McLeish
Jul 20, 2006·Journal of the Royal Society, Interface·Rhoda J Hawkins, Tom C B McLeish
Aug 15, 2006·Nature Structural & Molecular Biology·Nataliya PopovychCharalampos G Kalodimos
Oct 6, 2006·Journal of Molecular Evolution·Sandra MaguidJulián Echave
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Tong LiuVincent J Hilser
Jun 26, 2008·Gene·Sandra MaguidJulian Echave
Jul 17, 2008·Nature Reviews. Microbiology·Boris Görke, Jörg Stülke
Aug 27, 2009·Proceedings of the National Academy of Sciences of the United States of America·Ilya A BalabinDavid N Beratan
Nov 20, 2009·Nature·Shiou-Ru Tzeng, Charalampos G Kalodimos
Jan 30, 2010·International Journal of Molecular Sciences·Alan Brown
Apr 8, 2011·Bioinformatics·Ahmet BakanIvet Bahar
Apr 13, 2011·Proceedings of the National Academy of Sciences of the United States of America·Anastasia Zhuravleva, Lila M Gierasch
Jun 30, 2011·BMC Bioinformatics·Michael T ZimmermannRobert L Jernigan
Dec 27, 2011·Cell·Kimberly A ReynoldsRama Ranganathan
Mar 6, 2012·Proceedings of the National Academy of Sciences of the United States of America·Hesam N Motlagh, Vincent J Hilser
May 15, 2012·Annual Review of Biophysics·Vincent J HilserHesam N Motlagh
Jul 18, 2012·Nature·Shiou-Ru Tzeng, Charalampos G Kalodimos
Mar 1, 2013·The Journal of Physical Chemistry. B·Gregory ManleyJ Patrick Loria
Jun 14, 2013·BMC Bioinformatics·Thomas L RodgersTom C B McLeish
Aug 6, 2013·The FEBS Journal·Athel Cornish-Bowden
Apr 18, 2014·Nature·Hesam N MotlaghVincent J Hilser

❮ Previous
Next ❯

Citations

Oct 7, 2020·The Journal of Physiology·Sarbjit NijjarNicholas Dale
Jan 7, 2021·Journal of the Royal Society, Interface·Igors Dubanevics, Tom C B McLeish
May 17, 2017·Biophysics Reviews·Sam-Yong Park, Jeremy R H Tame
Jul 19, 2015·The Journal of Biological Chemistry·Philip D TownsendMartin J Cann
Apr 28, 2019·Molecular Biology and Evolution·She ZhangIvet Bahar
Mar 11, 2016·PLoS Computational Biology·Sarina GrutschMartin Tollinger
Apr 30, 2021·The Journal of Physical Chemistry. B·Yiǧit KutluTurkan Haliloglu
Oct 28, 2020·Journal of Chemical Information and Modeling·Akshay PrabhakantMarimuthu Krishnan
Jan 5, 2016·Chemical Reviews·Ranit Gruber, Amnon Horovitz

❮ Previous
Next ❯

Methods Mentioned

BETA
nuclear magnetic resonance
NMR
phosphotransferase
X-ray
isothermal titration calorimetry

Software Mentioned

MAVEN
ProDy
ENM
PDBMAT
elNémo
NMA
CAP

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.