Global map of SUMO function revealed by protein-protein interaction and genetic networks

Molecular Cell
Taras MakhnevychBrian Raught

Abstract

Systematic functional genomics approaches were used to map a network centered on the small ubiquitin-related modifier (SUMO) system. Over 250 physical interactions were identified using the SUMO protein as bait in affinity purification-mass spectrometry and yeast two-hybrid screens. More than 500 genes and 1400 synthetic genetic interactions were mapped by synthetic genetic array (SGA) analysis using eight different SUMO pathway query genes. The resultant global SUMO network highlights its role in 15 major biological processes and better defines functional relationships between the different components of the SUMO pathway. Using this information-rich resource, we have identified roles for the SUMO system in the function of the AAA ATPase Cdc48p, the regulation of lipid metabolism, localization of the ATP-dependent endonuclease Dna2p, and recovery from the DNA-damage checkpoint.

References

Apr 7, 1998·Molecular and Cellular Biology·F PâquesJ E Haber
Sep 12, 1998·Molecular Cell·J M DesterroR T Hay
Jun 12, 1999·Biochemical and Biophysical Research Communications·Y TakahashiY Kikuchi
Mar 14, 2000·Molecular and Cellular Biology·S J Li, M Hochstrasser
Jan 29, 2002·Nature Cell Biology·Ernst JaroschThomas Sommer
Feb 7, 2004·Science·Amy Hin Yan TongCharles Boone
Feb 26, 2004·Molecular Microbiology·Patrick DieckhoffStefan Irniger
Jun 11, 2004·Annual Review of Biochemistry·Erica S Johnson
Jul 10, 2004·Cell·Sanie MnaimnehTimothy R Hughes
Aug 5, 2004·The Journal of Biological Chemistry·Vikram Govind PanseEd Hurt
Aug 25, 2004·The Journal of Biological Chemistry·James A WohlschlegelJohn R Yates
Sep 25, 2004·Proceedings of the National Academy of Sciences of the United States of America·Jing SongYuan Chen
Nov 16, 2004·Molecular & Cellular Proteomics : MCP·Carilee DenisonSteven P Gygi
Dec 14, 2004·The Journal of Biological Chemistry·J Thomas HannichMark Hochstrasser
Dec 15, 2004·Molecular & Cellular Proteomics : MCP·Dennis D Wykoff, Erin K O'Shea
May 7, 2005·Nature Biotechnology·Ryan Kelley, Trey Ideker
Sep 17, 2005·Molecular and Cellular Biology·Robert WysockiStephen J Kron
Mar 10, 2006·The Journal of Biological Chemistry·Christina-Maria HeckerIvan Dikic
Oct 3, 2006·Nature Cell Biology·Meik SacherStefan Jentsch
Nov 2, 2006·Journal of Cell Science·Alison ReindleErica S Johnson
Apr 4, 2007·The Journal of Cell Biology·Taras MakhnevychRichard W Wozniak
May 15, 2007·Circulation Research·Joerg HerrmannAmir Lerman
May 19, 2007·Nature Reviews. Genetics·Charles BooneBrenda J Andrews
Aug 1, 2007·Molecular and Cellular Biology·David C SchwartzMark Hochstrasser
Aug 31, 2007·The Journal of Biological Chemistry·Kristina UzunovaR Jürgen Dohmen
Sep 1, 2007·The EMBO Journal·John PruddenMichael N Boddy
Nov 15, 2007·Nature Reviews. Molecular Cell Biology·Ruth Geiss-Friedlander, Frauke Melchior

❮ Previous
Next ❯

Citations

Sep 5, 2012·Nature Cell Biology·Peter H Thorpe, Rodney Rothstein
Jul 12, 2011·Nature Structural & Molecular Biology·Lisa E HangXiaolan Zhao
Apr 15, 2010·The Journal of Biological Chemistry·Henri A BlomsterLea Sistonen
Nov 19, 2010·The Journal of Biological Chemistry·Jonathan ShloushCheryl H Arrowsmith
Jan 21, 2011·The Journal of Biological Chemistry·Miklós BékésGuy S Salvesen
Aug 13, 2011·Molecular & Cellular Proteomics : MCP·Julio C BayonaVanina E Alvarez
Jul 28, 2010·Molecular Biology of the Cell·Justin HaworthAnja-Katrin Bielinsky
Jun 10, 2010·Bioinformatics·Ariel JaimovichNir Friedman
Apr 24, 2012·Database : the Journal of Biological Databases and Curation·Peter H ThorpeRodney Rothstein
May 28, 2010·Genes & Development·Emanuel RosoninaJames L Manley
Jul 22, 2010·Molecular and Cellular Biology·Yaroslav SydorskyyBrian Raught
Nov 1, 2011·BMC Biology·Zachary C ElmoreOliver Kerscher
Jul 29, 2010·Journal of Cell Science·Gonzalo Fernández-MirandaMarcos Malumbres
May 1, 2013·PLoS Biology·Kohila MahadevanAlexander F Palazzo
Oct 3, 2012·PloS One·Émilie BoudreauFrédérique Tesson
May 2, 2014·Science Signaling·Triin TammsaluRonald T Hay
Nov 21, 2012·Biochimica Et Biophysica Acta·Robyn D Moir, Ian M Willis
Aug 21, 2012·Cellular and Molecular Life Sciences : CMLS·Pedro Humberto CastroHerlânder Azevedo
Aug 22, 2012·The Journal of Cell Biology·Taras MakhnevychWalid A Houry
Apr 3, 2013·The Journal of Cell Biology·Tharan SrikumarBrian Raught
Jan 28, 2016·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Marco P Licciardello, Stefan Kubicek
May 29, 2013·Molecular Systems Biology·Tharan SrikumarBrian Raught
Sep 12, 2015·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Pierre ChymkowitchJorrit M Enserink
Sep 11, 2013·Biochimica Et Biophysica Acta·Annie M Sriramachandran, R Jürgen Dohmen
Feb 4, 2014·Current Biology : CB·Lisa M D'Ambrosio, Brigitte D Lavoie
Mar 26, 2014·Seminars in Cell & Developmental Biology·Yee Mon Thu, Anja-Katrin Bielinsky
Jan 19, 2013·Developmental Cell·Caelin Cubeñas-Potts, Michael J Matunis

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Cycle Pathways

Cell cycle is a complex process regulated by several signal transduction pathways and enzymes. Here is the latest research on regulation of cell cycle and cell cycle pathways.

Bioinformatics in Biomedicine

Bioinformatics in biomedicine incorporates computer science, biology, chemistry, medicine, mathematics and statistics. Discover the latest research on bioinformatics in biomedicine here.

Cell Checkpoints & Regulators

Cell cycle checkpoints are a series of complex checkpoint mechanisms that detect DNA abnormalities and ensure that DNA replication and repair are complete before cell division. They are primarily regulated by cyclins, cyclin-dependent kinases, and the anaphase-promoting complex/cyclosome. Here is the latest research.

Related Papers

The Journal of Biological Chemistry
James A WohlschlegelJohn R Yates
Molecular & Cellular Proteomics : MCP
Carilee DenisonSteven P Gygi
Trends in Biochemical Sciences
J Jefferson P PerryMichael N Boddy
Nature Reviews. Molecular Cell Biology
Ruth Geiss-Friedlander, Frauke Melchior
© 2021 Meta ULC. All rights reserved