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Global metabolic profiling procedures for urine using UPLC-MS

Nature Protocols

May 8, 2010

Elizabeth J WantJeremy K Nicholson

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Abstract

The production of 'global' metabolite profiles involves measuring low molecular-weight metabolites (<1 kDa) in complex biofluids/tissues to study perturbations in response to physiological challenges, toxic insults or disease processes. Information-rich analytical platforms, such as mas...read more

Mentioned in this Paper

Metabolic Process, Cellular
Urine
In Vivo NMR Spectroscopy
Mass Spectrometry
High Pressure Liquid Chromatography Procedure
Metabolite
Urine - SpecimenType
Spectrometry, Mass, Electrospray Ionization
Viral Markers
Metabolomics
2
493
Paper Details
References
  • References74
  • Citations207
12345...
  • References74
  • Citations207
12345...

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Evaluation of the repeatability of ultra-performance liquid chromatography-TOF-MS for global metabolic profiling of human urine samples

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Helen G GikaI D Wilson
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Global metabolic profiling procedures for urine using UPLC-MS

Nature Protocols

May 8, 2010

Elizabeth J WantJeremy K Nicholson

PMID: 20448546

DOI: 10.1038/nprot.2010.50

Abstract

The production of 'global' metabolite profiles involves measuring low molecular-weight metabolites (<1 kDa) in complex biofluids/tissues to study perturbations in response to physiological challenges, toxic insults or disease processes. Information-rich analytical platforms, such as mas...read more

Mentioned in this Paper

Metabolic Process, Cellular
Urine
In Vivo NMR Spectroscopy
Mass Spectrometry
High Pressure Liquid Chromatography Procedure
Metabolite
Urine - SpecimenType
Spectrometry, Mass, Electrospray Ionization
Viral Markers
Metabolomics
2
493

Feeds With Similar Papers

Metabolomics

Metabolomics refers to the large-scale study of profiling all metabolites in biological systems in a non-targeted manner. Here is the latest research.

Related Papers

Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences

Evaluation of the repeatability of ultra-performance liquid chromatography-TOF-MS for global metabolic profiling of human urine samples

Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life SciencesJune 27, 2008
Helen G GikaI D Wilson
Paper Details
References
  • References74
  • Citations207
12345...
  • References74
  • Citations207
12345...

Download from

Publisher
PubMed
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