Global metabolic responses of mice to Trypanosoma brucei brucei infection.

Proceedings of the National Academy of Sciences of the United States of America
Yulan WangE Holmes

Abstract

Human African trypanosomiasis (HAT) is transmitted by tsetse flies and, if untreated, is fatal. Treatment depends on infection stage, and early diagnosis is crucial for effective disease management. The systemic host biochemical changes induced by HAT that enable biomarker discovery or relate to therapeutic outcome are largely unknown. We have characterized the multivariate temporal responses of mice to Trypanosoma brucei brucei infection, using (1)H nuclear magnetic resonance (NMR) spectroscopic metabolic phenotyping of urine and plasma. Marked alterations in plasma metabolic profiles were detected already 1 day postinfection. Elevated plasma concentrations of lactate, branched chain amino acids, and acetylglycoprotein fragments were noted. T. brucei brucei-infected mice also had an imbalance of plasma alanine and valine, consistent with differential gluconeogenesis (parasite)-ketogenesis (host) pathway counterflux, involving stimulated host glycolysis, ketogenesis, and enhanced lipid oxidation in the host. Histopathologic evidence of T. brucei brucei-induced extramedullary hepatic hemopoiesis, renal interstitial nephritis, and a provoked inflammatory response was also noted. Metabolic disturbance of gut microbiotal activity w...Continue Reading

References

Jun 1, 1988·Molecular and Biochemical Parasitology·A SamadA Mellors
Jan 1, 1969·Transactions of the Royal Society of Tropical Medicine and Hygiene·H P Voorheis
Jan 1, 1995·Annual Review of Pharmacology and Toxicology·C C Wang
Mar 1, 1995·Analytical Chemistry·J K NicholsonJ C Lindon
Nov 20, 1998·Science·D Ebert
May 18, 1999·The Journal of Biological Chemistry·B M BakkerH V Westerhoff
May 30, 2001·Molecular and Biochemical Parasitology·A Acosta-SerranoS Schenkman
Jul 10, 2001·Journal of Bacteriology·L C BergerB J Berger
Jul 27, 2002·BMJ : British Medical Journal·August StichSanjeev Krishna
Nov 7, 2003·Lancet·Michael P BarrettSanjeev Krishna
Dec 19, 2003·Experimental Biology and Medicine·A DarsaudA Buguet
Feb 18, 2004·The Journal of Clinical Investigation·Peter G E Kennedy
Apr 28, 2004·Lancet·Marios C PapadopoulosSanjeev Krishna
Aug 18, 2004·Proceedings of the National Academy of Sciences of the United States of America·Yulan WangJürg Utzinger
Oct 9, 2004·Trends in Parasitology·Oliver Clyde HutchinsonMark Carrington
Jan 18, 2005·Clinical Microbiology Reviews·François ChappuisPhilippe Büscher
Jan 20, 2005·Journal of Agricultural and Food Chemistry·Yulan WangElaine Holmes
Mar 23, 2005·Trends in Parasitology·Dan AgranoffSanjeev Krishna
Apr 6, 2005·The Journal of Nutritional Biochemistry·Kirty S SolankyAedin Cassidy
Dec 13, 2005·Molecular and Biochemical Parasitology·Yulan WangElaine Holmes
Mar 21, 2006·International Journal for Parasitology·Peter G E Kennedy
Jun 1, 2006·Advances in Parasitology·E M FèvreI Maudlin
Dec 5, 2006·Anais Da Academia Brasileira De Ciências·Philippe Vincendeau, Bernard Bouteille
Jun 6, 2007·Transactions of the Royal Society of Tropical Medicine and Hygiene·Peter G E Kennedy
Jul 10, 2007·British Journal of Pharmacology·M P BarrettR R Tidwell
Sep 7, 2007·The New England Journal of Medicine·Peter J HotezLorenzo Savioli

❮ Previous
Next ❯

Citations

May 6, 2010·Parasitology·E Holmes
Nov 10, 2010·Journal of Proteome Research·Yumiko NakanishiJun Kikuchi
Apr 2, 2011·Journal of Proteome Research·Ji-Hyun ShinGeum-Sook Hwang
Aug 1, 2012·Journal of Proteome Research·Xiu-Ju ZhaoYulan Wang
Jan 25, 2013·Journal of Proteome Research·Hannah J LeesElaine Holmes
Jun 8, 2012·Science Translational Medicine·Elaine HolmesJeremy K Nicholson
Apr 11, 2013·Antimicrobial Agents and Chemotherapy·Darren J CreekMichael P Barrett
Jul 21, 2011·Journal of Parasitology Research·Arjun SenguptaHaripalsingh M Sonawat
Jul 4, 2008·PLoS Neglected Tropical Diseases·Jasmina SaricJürg Utzinger
Sep 9, 2010·PLoS Neglected Tropical Diseases·Junfang WuYulan Wang
Oct 20, 2010·PLoS Neglected Tropical Diseases·Judith R DeneryKim D Janda
Jan 8, 2011·The American Journal of Tropical Medicine and Hygiene·Jia V LiOliver Balmer
Jan 1, 2011·Expert Opinion on Medical Diagnostics·Carolyn M Slupsky
May 23, 2012·Trends in Ecology & Evolution·Alan A CohenJennifer A Dunne
Jul 29, 2010·Molecular Systems Biology·Jasmina SaricElaine Holmes
Aug 27, 2015·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Justine SwannElizabeth A Winzeler
Oct 27, 2011·Molecular and Biochemical Parasitology·Darren J CreekMichael P Barrett
Dec 3, 2009·International Journal for Parasitology·Jun-Fang WuYu-Lan Wang
Feb 18, 2010·Cell Host & Microbe·Björn F C Kafsack, Manuel Llinás
Nov 5, 2014·Journal of Proteome Research·Sabrina D LamourJasmina Saric
Sep 21, 2017·The Journal of Infectious Diseases·Sabrina D LamourJeremy M Sternberg
Mar 9, 2018·Proteomics. Clinical Applications·Natalia Tiberti, Jean-Charles Sanchez
Jan 16, 2015·Molecular BioSystems·Qianfen WanYulan Wang
Sep 17, 2009·Magnetic Resonance in Chemistry : MRC·Huiru TangYulan Wang
Aug 19, 2014·Molecular BioSystems·Limiao JiangYulan Wang

❮ Previous
Next ❯

Related Concepts

Related Feeds

African Trypanosomiasis

African trypanosomiasis, also known as sleeping sickness, is an insect-borne parasitic disease of humans and other animals. It is caused by protozoa of the species Trypanosoma brucei and almost invariably progresses to death unless treated. Discover the latest research on African trypanosomiasis here.