Global migration of clinical research during the era of trial registration

PloS One
Paul K DrainIngrid V Bassett

Abstract

Since the site of human subjects research has public health, regulatory, ethical, economic, and social implications, we sought to determine the global distribution and migration of clinical research using an open-access trial registry. We obtained individual clinical trial data including location of trial sites, dates of operation, funding source (United States government, pharmaceutical industry, or organization), and clinical study phase (1, 1/2, 2, 2/3, or 3) from ClinicalTrials.gov. We used the World Bank's classification of each country's economic development status ["High Income and a Member of the Organization for Economic Co-operation and Development (OECD)", "High Income and Non-Member of the OECD", "Upper-Middle Income", "Lower-Middle Income", or "Low Income"] and United Nations Populations Division data for country-specific population estimates. We analyzed data from calendar year 2006 through 2012 by number of clinical trial sites, cumulative trial site-years, trial density (trial site-years/106 population), and annual growth rate (%) for each country, and by development category, funding source, and clinical study phase. Over a 7-year period, 89,647 clinical trials operated 784,585 trial sites in 175 countries, con...Continue Reading

Citations

Aug 29, 2018·Intensive Care Medicine·Perrine JaniaudJohn P A Ioannidis
Sep 10, 2019·Annals of Internal Medicine·David J Whellan
Apr 28, 2020·JNCI Cancer Spectrum·Teresa de RojasJulien Péron
Mar 14, 2020·BMC Health Services Research·Ana A Baumann, Leopoldo J Cabassa
Apr 25, 2021·Clinical Pharmacology and Therapeutics·Larissa WenningJennifer E Hibma

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