Global mistranslation increases cell survival under stress in Escherichia coli

PLoS Genetics
Laasya SamhitaD. Agashe

Abstract

Mistranslation is typically deleterious for cells, although specific mistranslated proteins can confer a short-term benefit in a particular environment. However, given its large overall cost, the prevalence of high global mistranslation rates remains puzzling. Altering basal mistranslation levels of Escherichia coli in several ways, we show that generalized mistranslation enhances early survival under DNA damage, by rapidly activating the SOS response. Mistranslating cells maintain larger populations after exposure to DNA damage, and thus have a higher probability of sampling critical beneficial mutations. Both basal and artificially increased mistranslation increase the number of cells that are phenotypically tolerant and genetically resistant under DNA damage; they also enhance survival at high temperature. In contrast, decreasing the normal basal mistranslation rate reduces cell survival. This wide-ranging stress resistance relies on Lon protease, which is revealed as a key effector that induces the SOS response in addition to alleviating proteotoxic stress. The new links between error-prone protein synthesis, DNA damage, and generalised stress resistance indicate surprising coordination between intracellular stress response...Continue Reading

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Citations

Sep 10, 2020·RNA Biology·Matthew D Berg, Christopher J Brandl
Nov 18, 2020·The Journal of Biological Chemistry·Sunil Shetty, Umesh Varshney
Jan 26, 2021·Evolution; International Journal of Organic Evolution·Laasya SamhitaDeepa Agashe
Jan 19, 2021·The Journal of Biological Chemistry·Sunil Shetty, Umesh Varshney
Jul 6, 2021·Frontiers in Cell and Developmental Biology·Ulrich Karl Steiner
Jul 14, 2021·Molecular Biology and Evolution·Jia ZhengAndreas Wagner
Aug 21, 2021·Proceedings of the National Academy of Sciences of the United States of America·Oscar Vargas-RodriguezSergey Melnikov
Nov 5, 2021·History and Philosophy of the Life Sciences·Emmanuel Saridakis

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Methods Mentioned

BETA
aminoacylation

Software Mentioned

Biolog

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