Global patterns of linkage disequilibrium at the CD4 locus and modern human origins

Science
S A TishkoffM Krings

Abstract

Haplotypes consisting of alleles at a short tandem repeat polymorphism (STRP) and an Alu deletion polymorphism at the CD4 locus on chromosome 12 were analyzed in more than 1600 individuals sampled from 42 geographically dispersed populations (13 African, 2 Middle Eastern, 7 European, 9 Asian, 3 Pacific, and 8 Amerindian). Sub-Saharan African populations had more haplotypes and exhibited more variability in frequencies of haplotypes than the Northeast African or non-African populations. The Alu deletion was nearly always associated with a single STRP allele in non-African and Northeast African populations but was associated with a wide range of STRP alleles in the sub-Saharan African populations. This global pattern of haplotype variation and linkage disequilibrium suggests a common and recent African origin for all non-African human populations.

References

Nov 1, 1992·Genomics·M C Edwards, R A Gibbs
Dec 1, 1991·Journal of Molecular Evolution·D A MerriwetherD C Wallace
Feb 7, 1992·Science·S B HedgesM Stoneking
Sep 27, 1991·Science·L VigilantA C Wilson
Sep 11, 1991·Nucleic Acids Research·M C EdwardsR A Gibbs
Feb 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·A M BowcockL L Cavalli-Sforza
Feb 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·M RuvoloR L Honeycutt
Mar 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·A Di Rienzo, A C Wilson
Jan 1, 1987·Nature·R L CannA C Wilson
Feb 6, 1986·Nature·J S Jones, S Rouhani
Mar 11, 1988·Science·C B Stringer, P Andrews
Aug 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·L L Cavalli-SforzaJ Mountain
Aug 1, 1969·Proceedings of the National Academy of Sciences of the United States of America·A C Wilson, V M Sarich
Nov 1, 1981·Tissue Antigens·B O Bengtsson, G Thomson
Nov 23, 1995·Nature·M F Hammer
Nov 23, 1995·Nature·L S WhitfieldP N Goodfellow
Mar 31, 1994·Nature·A M BowcockL L Cavalli-Sforza
Jan 17, 1995·Proceedings of the National Academy of Sciences of the United States of America·S HoraiN Takahata
Jul 18, 1995·Proceedings of the National Academy of Sciences of the United States of America·D B GoldsteinM W Feldman
Jan 1, 1995·Genetics·D B GoldsteinM W Feldman
Dec 1, 1994·Current Opinion in Genetics & Development·D Tautz, Schlötterer
Dec 6, 1994·Proceedings of the National Academy of Sciences of the United States of America·M A BatzerR J Herrera
Jul 19, 1994·Proceedings of the National Academy of Sciences of the United States of America·F J AyalaJ Klein
Jul 19, 1994·Proceedings of the National Academy of Sciences of the United States of America·Y SattaJ Klein
Feb 25, 1994·Science·C C Swisher Widiasmoro
Apr 12, 1994·Proceedings of the National Academy of Sciences of the United States of America·A Di RienzoN B Freimer
Oct 1, 1993·Journal of Molecular Evolution·M HasegawaA C Wilson
Aug 1, 1993·Human Molecular Genetics·J L Weber, C Wong
May 1, 1993·Molecular and Cellular Biology·F P GillespieS C Wadsworth

❮ Previous
Next ❯

Citations

Mar 30, 1999·American Journal of Physical Anthropology·J H Relethford, L B Jorde
Jun 19, 1998·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·L B JordeA R Rogers
Jun 22, 2000·American Journal of Physical Anthropology·G Destro-BisolG Spedini
Jul 12, 2002·American Journal of Human Biology : the Official Journal of the Human Biology Council·Fabiana Michelsen De AndradeMara Helena Hutz
Aug 16, 2001·American Journal of Human Biology : the Official Journal of the Human Biology Council·S O Keita, A J Boyce
Sep 5, 2002·American Journal of Physical Anthropology·Michael V OsierKenneth K Kidd
Sep 27, 2002·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Yoko Satta, Naoyuki Takahata
Dec 1, 1996·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·C Wills
Jan 1, 1997·Journal of Molecular Evolution·R M HardingJ B Clegg
Jan 1, 1997·Journal of Molecular Evolution·S Easteal, G Herbert
Aug 8, 2007·Human Genetics·Vania YotovaDamian Labuda
Jul 17, 2008·Human Genetics·Francesc CalafellAntoine Blancher
Oct 19, 2011·Human Genetics·Asif JavedUNKNOWN Genographic Consortium
Mar 25, 2006·Journal of Human Genetics·Erica M Shepard, Rene J Herrera
Jun 10, 2004·Molecular Phylogenetics and Evolution·Derek E WildmanTodd R Disotell
Apr 26, 2003·Mutation Research·Benjamin A SalisburyJ Claiborne Stephens
Mar 19, 2003·Lancet·Helen M ColhounGeorge Davey Smith
Nov 28, 1997·Journal of Reproductive Immunology·T V HviidN Morling
Apr 1, 1998·Trends in Genetics : TIG·L L Cavalli-Sforza
Apr 27, 2000·Trends in Ecology & Evolution·P Sunnucks
Jul 9, 1999·Gene·A J Brookes
Apr 20, 2001·Forensic Science International : Synergy·L Quintana-MurciK McElreavey
Mar 7, 2003·Genomics·Benjamin FletcherMark G Thomas
Oct 30, 2001·Current Opinion in Genetics & Development·C F AquadroF A Reed
Oct 30, 2001·Current Opinion in Genetics & Development·P Andolfatto
Nov 16, 2002·Current Opinion in Genetics & Development·Laurent Excoffier
Feb 20, 1998·Current Opinion in Genetics & Development·A R Templeton
Dec 28, 1999·Trends in Cell Biology·S Pääbo
Feb 6, 2002·Current Opinion in Chemical Biology·Maido Remm, Andres Metspalu
Nov 15, 2000·Clinical Genetics·N J SchorkJ S Lanchbury
Jan 12, 2005·The American Psychologist·Robert J SternbergKenneth K Kidd
Mar 7, 2008·Heredity·J H Relethford
Oct 1, 2010·Journal of Human Genetics·Wifak El MoncerHassen Chaabani
Jun 1, 1996·Nature Genetics·J A ArmourA J Jeffreys
Oct 1, 1996·Nature Genetics·A von HaeselerS Pääbo
Jan 20, 2010·Nature Reviews. Genetics·Yik-Ying TeoDominic P Kwiatkowski
Sep 17, 2011·Nature Reviews. Genetics·Sharon R Browning, Brian L Browning
Jan 20, 2005·European Journal of Human Genetics : EJHG·Sarah L SawyerKenneth K Kidd

❮ Previous
Next ❯

Related Concepts

Related Feeds

CZI Human Cell Atlas Seed Network

The aim of the Human Cell Atlas (HCA) is to build reference maps of all human cells in order to enhance our understanding of health and disease. The Seed Networks for the HCA project aims to bring together collaborators with different areas of expertise in order to facilitate the development of the HCA. Find the latest research from members of the HCA Seed Networks here.