Global phylogeography and genetic diversity of the zoonotic tapeworm Echinococcus granulosus sensu stricto genotype G1

International Journal for Parasitology
Liina KinkarUrmas Saarma

Abstract

Echinococcus granulosus sensu stricto (s.s.) is the major cause of human cystic echinococcosis worldwide and is listed among the most severe parasitic diseases of humans. To date, numerous studies have investigated the genetic diversity and population structure of E. granulosus s.s. in various geographic regions. However, there has been no global study. Recently, using mitochondrial DNA, it was shown that E. granulosus s.s. G1 and G3 are distinct genotypes, but a larger dataset is required to confirm the distinction of these genotypes. The objectives of this study were to: (i) investigate the distinction of genotypes G1 and G3 using a large global dataset; and (ii) analyse the genetic diversity and phylogeography of genotype G1 on a global scale using near-complete mitogenome sequences. For this study, 222 globally distributed E. granulosus s.s. samples were used, of which 212 belonged to genotype G1 and 10 to G3. Using a total sequence length of 11,682 bp, we inferred phylogenetic networks for three datasets: E. granulosus s.s. (n = 222), G1 (n = 212) and human G1 samples (n = 41). In addition, the Bayesian phylogenetic and phylogeographic analyses were performed. The latter yielded several strongly supported diffusion routes ...Continue Reading

Citations

Mar 29, 2019·Vector Borne and Zoonotic Diseases·Mohammad Reza LashkarizadehMajid Fasihi Harandi
Dec 22, 2019·Parasitology Research·Christian HidalgoCristian A Alvarez Rojas
Jun 6, 2020·Parasite : Journal De La Société Française De Parasitologie·Dominique A VuittonUNKNOWN World Association of Echinococcosis
Nov 30, 2019·Journal of Helminthology·J A OhioleiW-Z Jia
Nov 22, 2019·Journal of Parasitic Diseases : Official Organ of the Indian Society for Parasitology·Behnam AbediReza Ghasemikhah
Jan 30, 2020·Revista Da Sociedade Brasileira De Medicina Tropical·Daniel JarovskyMário Luiz de la Rue
Nov 13, 2020·Parasites & Vectors·Andrea CordaMaria Luisa Pinna Parpaglia
Apr 4, 2021·Pathogens·Puspa M SharmaPeter Deplazes
Mar 25, 2021·Parasitology·Gaelle JoannyAntonio Scala
Apr 18, 2021·Parasitology Research·Fahad A Al-HizabRihab A Omer
Jul 16, 2021·Acta Parasitologica·Gaelle JoannyAntonio Varcasia
Aug 4, 2021·Parasitology Research·Daouia MoussaChristophe Hennequin
Apr 8, 2020·Parasitology International·Piero BonelliGiovanna Masala

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