Global Plasma Profiling for Colorectal Cancer-Associated Volatile Organic Compounds: a Proof-of-Principle Study

Journal of Chromatographic Science
Seongho KimIkuko Kato

Abstract

Volatile organic compounds (VOCs) could reflect changes resulting from ongoing pathophysiological processes and altered body metabolisms, and thus have been studied for various types of cancers. We aimed to test an advanced global metabolomic technique to characterize circulating VOCs in patients diagnosed with colorectal cancer (CRC). We employed solid-phase microextraction (SPME) and comprehensive two-dimensional gas chromatography mass-spectrometry (GC × GC-MS). We analyzed 30 random plasma samples from incident cases of CRC. The 30 samples were from population controls enrolled in a large population-based case-control study. The number of metabolite peaks detected in the cases was significantly lower than that detected in the controls (median 1530 vs. 1694, P = 0.02). Partial least squares-discriminant analysis showed clear VOC profile differences between the CRC and the controls. After adjustment for multiple comparisons at the 5% false discovery rate level, five VOCs were differentially expressed between the cases and the controls. Among these five VOCs, 2,3,4-trimethyl-hexane (decreased) and 2,4-dimethylhept-1-ene (increased) were both lipid peroxidation products but not previously reported for CRC. In summary, this stud...Continue Reading

References

Jul 20, 1999·Journal of Chromatography. B, Biomedical Sciences and Applications·M PhillipsR N Cataneo
Jun 11, 2003·Chest·Michael PhillipsWilliam N Rom
Oct 10, 2006·Dental Materials : Official Publication of the Academy of Dental Materials·Christophe ChartonFernand Pla
Feb 23, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Catherine E GarnerNorman M Ratcliffe
Oct 22, 2008·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Sandra Van den VeldeMarc Quirynen
Dec 10, 2009·International Journal of Cancer. Journal International Du Cancer·Ikuko KatoRichard K Severson
Dec 23, 2009·World Journal of Gastroenterology : WJG·Kajsa KajanderRiitta Korpela
Feb 13, 2010·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Diana PoliAntonio Mutti
Mar 24, 2010·Cancer Epidemiology·Ikuko KatoRichard K Severson
Oct 21, 2010·Cancer Research·Vincent M AsiagoDaniel Raftery
Aug 5, 2011·Journal of Chromatography. a·Jun ZhangXiang Zhang
Sep 21, 2012·Chemical Reviews·Meggie HakimHossam Haick
Jul 28, 2013·Journal of Proteome Research·Kishore Kumar PasikantiEric Chun Yong Chan
Aug 30, 2013·Nature·Emmanuelle Le ChatelierOluf Pedersen
Aug 30, 2013·Nature·Aurélie CotillardStanislav Dusko Ehrlich
Oct 9, 2013·Cancer Biology & Therapy·Changsong WangEnyou Li
Dec 7, 2013·Chemical Society Reviews·Hossam HaickAnton Amann
May 14, 2014·Analytical and Bioanalytical Chemistry·Changsong WangEnyou Li
Mar 5, 2015·Journal of Proteome Research·Jason H WinnikeXiang Zhang
Sep 1, 2015·Journal of Biomarkers·Kamila Schmidt, Ian Podmore
Oct 7, 2015·Oncotarget·Agne KrilaviciuteHermann Brenner
Dec 15, 2015·The Cochrane Database of Systematic Reviews·Brian D NicholsonDavid Mant
Jan 12, 2016·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·Maria Di LenaDonato Francesco Altomare
May 11, 2016·Current Medicinal Chemistry·Wojciech FilipiakJakob Troppmair
Jul 15, 2016·Nature·Helle Krogh PedersenOluf Pedersen

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