Global prevalence of diabetes in active tuberculosis: a systematic review and meta-analysis of data from 2·3 million patients with tuberculosis

The Lancet Global Health
Jean Jacques N NoubiapJean Joel R Bigna

Abstract

Although diabetes and poor glycaemic control significantly increase the risk of tuberculosis and adversely affect tuberculosis treatment outcomes, the global burden of diabetes in the context of tuberculosis remains unknown. We did a systematic review and meta-analysis to estimate the prevalence of diabetes among patients with tuberculosis at global, regional, and country levels. We searched PubMed, Excerpta Medica Database, Web of Science, and Global Index Medicus to identify studies published between Jan 1, 1986, and June 15, 2017, on the prevalence of diabetes in patients with active tuberculosis, with no language restrictions. Criteria to diagnose tuberculosis and diabetes concurred with WHO guidelines. Methodological quality of eligible studies was assessed, and random-effect models meta-analysis served to obtain the pooled prevalence estimate of diabetes among patients with active tuberculosis, globally. Heterogeneity (I2) was assessed via the χ2 test on Cochran's Q statistic. This study is registered with PROSPERO, number CRD42016049901. We screened 7565 records of which 200 studies (2 291 571 people with active tuberculosis) were included in meta-analyses. The pooled prevalence of diabetes was 15·3% (95% prediction inte...Continue Reading

Citations

Mar 21, 2019·International Endodontic Journal·V NagendrababuP M H Dummer
Dec 10, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Steve LeumiJean Jacques Noubiap
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