Global sensitivity analysis of the joint kinematics during gait to the parameters of a lower limb multi-body model

Medical & Biological Engineering & Computing
A El HabachiR Dumas

Abstract

Sensitivity analysis is a typical part of biomechanical models evaluation. For lower limb multi-body models, sensitivity analyses have been mainly performed on musculoskeletal parameters, more rarely on the parameters of the joint models. This study deals with a global sensitivity analysis achieved on a lower limb multi-body model that introduces anatomical constraints at the ankle, tibiofemoral, and patellofemoral joints. The aim of the study was to take into account the uncertainty of parameters (e.g. 2.5 cm on the positions of the skin markers embedded in the segments, 5° on the orientation of hinge axis, 2.5 mm on the origin and insertion of ligaments) using statistical distributions and propagate it through a multi-body optimisation method used for the computation of joint kinematics from skin markers during gait. This will allow us to identify the most influential parameters on the minimum of the objective function of the multi-body optimisation (i.e. the sum of the squared distances between measured and model-determined skin marker positions) and on the joint angles and displacements. To quantify this influence, a Fourier-based algorithm of global sensitivity analysis coupled with a Latin hypercube sampling is used. This...Continue Reading

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Citations

Apr 22, 2017·Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine·Iain HannahClaudia Mazzà
Feb 6, 2018·Journal of Biomechanical Engineering·Hosein Naseri, Håkan Johansson
Jan 1, 2016·Journal of Biomechanical Engineering·Alessandro NavacchiaKevin B Shelburne
Apr 20, 2019·Computer Methods in Biomechanics and Biomedical Engineering·Eric JacquelinRaphael Dumas
Apr 12, 2020·Journal of the Mechanical Behavior of Biomedical Materials·H NaseriH Johansson
Mar 12, 2020·Journal of Biomechanics·Santiago Arroyave-TobónJean-Marc Linares
Jul 30, 2021·Frontiers in Bioengineering and Biotechnology·Joris De RoeckEmmanuel A Audenaert
Aug 31, 2021·Journal of Biomechanics·Todd J HullfishJosh R Baxter

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