Global survey of genetic variation in CCR5, RANTES, and MIP-1alpha: impact on the epidemiology of the HIV-1 pandemic

Proceedings of the National Academy of Sciences of the United States of America
E GonzalezSunil K Ahuja

Abstract

Expression of CC chemokine receptor 5 (CCR5), the major coreceptor for HIV-1 cell entry, and its ligands (e.g., RANTES and MIP-1alpha) is widely regarded as central to the pathogenesis of HIV-1 infection. By surveying nearly 3,000 HIV+ and HIV- individuals from worldwide populations for polymorphisms in the genes encoding RANTES, MIP-1alpha, and CCR5, we show that the evolutionary histories of human populations have had a significant impact on the distribution of variation in these genes, and that this may be responsible, in part, for the heterogeneous nature of the epidemiology of the HIV-1 pandemic. The varied distribution of RANTES haplotypes (AC, GC, and AG) associated with population-specific HIV-1 transmission- and disease-modifying effects is a striking example. Homozygosity for the AC haplotype was associated with an increased risk of acquiring HIV-1 as well as accelerated disease progression in European Americans, but not in African Americans. Yet, the prevalence of the ancestral AC haplotype is high in individuals of African origin, but substantially lower in non-Africans. In a Japanese cohort, AG-containing RANTES haplotype pairs were associated with a delay in disease progression; however, we now show that their con...Continue Reading

References

Jan 1, 1989·Journal of Clinical Epidemiology·M J AdamsL M James
Jan 1, 1988·Journal of Mathematical Biology·K Dietz, K P Hadeler
May 1, 1974·American Journal of Epidemiology·O S Miettinen
Jun 1, 1997·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·E A OperskalskiD O Stram
May 9, 1998·Proceedings of the National Academy of Sciences of the United States of America·D ZaguryR C Gallo
Apr 14, 1999·Proceedings of the National Academy of Sciences of the United States of America·H LiuT Shioda
Jul 27, 1999·Proceedings of the Association of American Physicians·J B Clegg, D J Weatherall
Jul 27, 1999·Proceedings of the Association of American Physicians·R A Kaslow, J M McNicholl
Oct 16, 1999·Proceedings of the National Academy of Sciences of the United States of America·A Garzino-DemoR C Gallo
Oct 16, 1999·Proceedings of the National Academy of Sciences of the United States of America·E GonzalezS K Ahuja
Oct 27, 1999·Journal of Clinical Immunology·R C GalloA L DeVico

❮ Previous
Next ❯

Citations

Feb 12, 2008·AIDS and Behavior·Andrew J LevinePaul Shapshak
Jun 5, 2002·Journal of Neuroimmunology·Peter A CalabresiKatharine A Whartenby
Jan 5, 2007·Nature Reviews. Microbiology·Kevin K AriënEric J Arts
Dec 16, 2005·Cell Research·Tuo Fu ZhuBo Ping Zhou
Jan 5, 2005·The Journal of Infectious Diseases·Richard A KaslowJames Jianming Tang
Apr 12, 2003·AIDS Research and Human Retroviruses·Thomas J KetasJohn P Moore
Sep 7, 2002·Genetic Testing·S KhaliqS Qasim Mehdi
Feb 24, 2005·AIDS Research and Human Retroviruses·Ming LiChunfu Yang
May 29, 2007·AIDS Research and Human Retroviruses·Yusuke KoizumiHiroshi Ichimura
Nov 27, 2008·AIDS Research and Human Retroviruses·Yuan QianJiayou Chu
Feb 4, 2011·The Journal of Infectious Diseases·Gabriel CatanoSunil K Ahuja
Jul 28, 2009·Molecular Biology and Evolution·Luke G BarrettJeremy J Burdon
Nov 2, 2002·Molecular Biology and Evolution·Matthew V Rockman, Gregory A Wray
Nov 21, 2002·AIDS·Jianming TangUNKNOWN REACH Study Group. Reaching for Excellence in Adolescent Care and Health
Jul 19, 2006·AIDS·Michael J SilverbergUNKNOWN Tri-Service AIDS Clinical Consortium Natural History Study Group
Nov 30, 2005·Transplantation·Eleonora SimeoniSylvain Fleury
Apr 3, 2009·Current Opinion in HIV and AIDS·William C Olson, Jeffrey M Jacobson
Dec 17, 2010·AIDS·Slavé PetrovskiUNKNOWN Center for HIV/AIDS Vaccine Immunology
Jun 10, 2010·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Efe SezginUNKNOWN SOCA Research Group
Dec 17, 2009·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Taras K OleksykStephen J O'Brien
Mar 3, 2005·Journal of Gastroenterology and Hepatology·Stephan HellmigStefan Schreiber
Oct 7, 2003·Annual Review of Genomics and Human Genetics·Sarah A Tishkoff, Brian C Verrelli
Jun 25, 2005·American Journal of Respiratory and Critical Care Medicine·Paolo SpagnoloKenneth I Welsh

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.