Global transcriptional response of pig brain and lung to natural infection by Pseudorabies virus.

BMC Microbiology
J F YuanN A Affara

Abstract

Pseudorabies virus (PRV) is an alphaherpesviruses whose native host is pig. PRV infection mainly causes signs of central nervous system disorder in young pigs, and respiratory system diseases in the adult. In this report, we have analyzed native host (piglets) gene expression changes in response to acute pseudorabies virus infection of the brain and lung using a printed human oligonucleotide gene set from Illumina. A total of 210 and 1130 out of 23,000 transcript probes displayed differential expression respectively in the brain and lung in piglets after PRV infection (p-value < 0.01), with most genes displaying up-regulation. Biological process and pathways analysis showed that most of the up-regulated genes are involved in cell differentiation, neurodegenerative disorders, the nervous system and immune responses in the infected brain whereas apoptosis, cell cycle control, and the mTOR signaling pathway genes were prevalent in the infected lung. Additionally, a number of differentially expressed genes were found to map in or close to quantitative trait loci for resistance/susceptibility to pseudorabies virus in piglets. This is the first comprehensive analysis of the global transcriptional response of the native host to acute ...Continue Reading

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Citations

Jun 1, 2012·American Journal of Physiology. Renal Physiology·Wenbin YangDavid J Klumpp
Nov 16, 2014·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Martine Schroyen, Christopher K Tuggle
Aug 14, 2019·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Xue YangYiming Liu

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Methods Mentioned

BETA
Chip
PCR
ubiquitination
transcription

Software Mentioned

Express Primer
FSPMA
Homologene
ArrayExpress
BLAST
Pathway
YASMA
Onto
Bluefuse
R package

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