Abstract
Pigs are important, both for agriculture and as animal models for human diseases. However, due to the lack of embryonic stem cells, the possibility of genetic modification is quite limited. To overcome this limitation, induced pluripotent stem (iPS) cells have been derived from pigs. Despite the public availability of a large number of expression datasets from mice, rats, and primates-derived iPS cells, the expression profile of pig-derived iPS cells is quite limited. Furthermore, there is no dataset focused on the profiling of pig-derived iPS cell with six reprogramming factors (Oct3/4, Sox2, Klf4, c-Myc, Lin28, and Nanog). Here, we used Illumina RNA sequencing platform to characterize the mRNA expression of four-factor derived and six-factor derived pig iPS cells. We observed that the expression levels of whole genes in our established six factors derived iPS cells and parent fibroblast, and compared with that of iPS cells with four factors in public database. These data are valuable in understanding species difference in the reprogramming process of stem cells, and could help identify the key regulating genes involved in the process.
References
Nov 6, 1998·Science·J A ThomsonJ M Jones
Jun 8, 2007·Nature·Keisuke OkitaShinya Yamanaka
Nov 24, 2007·Cell·Kazutoshi TakahashiShinya Yamanaka
Dec 27, 2008·Cell·Ping LiQi-Long Ying
Apr 21, 2009·The Journal of Biological Chemistry·Miguel A EstebanDuanqing Pei
Jun 6, 2009·Cell Stem Cell·Jennifer Nichols, Austin Smith
Jun 9, 2009·Journal of Molecular Cell Biology·Zhao WuLei Xiao
Jun 23, 2009·Proceedings of the National Academy of Sciences of the United States of America·Toshihiko EzashiR Michael Roberts
Sep 10, 2009·Cell Cycle·R Michael RobertsToshihiko Ezashi
Apr 13, 2010·Stem Cells and Development·Franklin D WestSteven L Stice
Jan 25, 2011·Cellular Reprogramming·Lizhen HuangLiangxue Lai
Jun 28, 2011·Science China. Life Sciences·WeiMin RuanNing Li
Apr 6, 2012·Algorithms for Molecular Biology : AMB·Koji KadotaKentaro Shimizu
Aug 15, 2012·Stem Cells and Development·Shuh-hei FujishiroYutaka Hanazono
Oct 6, 2012·Cellular Reprogramming·Kai LiuLin Liu
Dec 20, 2012·PloS One·De ChengHuayan Wang
Jul 11, 2013·BMC Bioinformatics·Jianqiang SunKoji Kadota
Oct 1, 2013·Cell·Daniel C KoboldtElaine R Mardis
Oct 8, 2013·PloS One·Guangzhen JiLin Liu
Aug 5, 2014·Cell Stem Cell·Thorold W TheunissenRudolf Jaenisch
Sep 13, 2014·Cell·Yasuhiro TakashimaAustin Smith
Feb 11, 2016·Nature Reviews. Molecular Cell Biology·Leehee WeinbergerJacob H Hanna
Oct 28, 2016·Journal of Cellular Biochemistry·Tomokazu FukudaArata Honda
Jan 4, 2017·Stem Cell Reports·Jian MaoLin Liu
Citations
Mar 27, 2020·Frontiers in Cell and Developmental Biology·Werner Giehl GlanznerVilceu Bordignon
Jan 28, 2020·The Journal of Reproduction and Development·Seiki HaraguchiTomoyuki Tokunaga
Jan 14, 2021·IScience·Tomokazu FukudaTsuyoshi Ishii
May 9, 2021·Scientific Data·Kai FuruyaTomokazu Fukuda