journal cover

Global Transcriptome Analysis of RNA Abundance Regulation by ADAR in Lung Adenocarcinoma

EBioMedicine

Dec 24, 2017

Michael F SharpnackKun Huang

Abstract

Despite tremendous advances in targeted therapies against lung adenocarcinoma, the majority of patients do not benefit from personalized treatments. A deeper understanding of potential therapeutic targets is crucial to increase the survival of patients. One promising target, ADAR, is am...read more

Mentioned in this Paper

Study
Biochemical Pathway
Adenocarcinoma of Lung (Disorder)
Gene Expression Regulation, Neoplastic
Gene Dosage
Apolipoprotein L1
ADAR
Apoptosis, Intrinsic Pathway
APOL1 protein, human
Gene Amplification
8
27

Similar Papers Found In These Feeds

Epigenome Engineering (Keystone)

Recent advances in epigenome engineering technologies allow now for the large-scale assessment of the functional relevance of DNA methylation. Discover the latest research here.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Epigenome Engineering

Recent advances in epigenome engineering technologies allow now for the large-scale assessment of the functional relevance of dna methylation. Discover the latest research here.

RNA Binding Proteins

This feed focuses on RNA Binding Proteins, which are involved in post-transcriptional processes, such as alternative splicing, RNA transport, localization and function.

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Human Lung Cell Atlas

Examining the genomics, transcriptomics, proteomics, and metabolomics of the human lung at the single cell level will help build a single cell atlas of the lungs, which would give a unique ID card for each cell type, a three-dimensional map of how cell types work together to form tissues, and insights into how changes in the map underlie health and disease of the lungs. Discover the latest research on the human cell lung atlas here.

Inosine: Parkinson's Disease

Parkinson’s disease (PD) is a progressive neurodegenerative disorder that affects movement. Drug Inosine is proposed to slow progression of this disease. Here is the latest research on Inosine in PD.

MicroRNAs & Open Reading Frames

MicroRNAs are small non-coding RNAs that modulate gene expression at post-transcriptional level, playing a crucial role in cell differentiation and development. Discover the latest research on MicroRNAs & how they target Open Reading Frames.

RNA Editing and ADAR Enzymes

ADAR enzymes are responsible for a-to-i rna editing, an essential post-transcriptional rna modification contributing to transcriptome and proteome diversification.

Human Lung Cell Atlas

Examining the genomics, transcriptomics, proteomics, and metabolomics of the human lung at the single cell level will help build a single cell atlas of the lungs, which would give a unique ID card for each cell type, a three-dimensional map of how cell types work together to form tissues, and insights into how changes in the map underlie health and disease of the lungs. Discover the latest research on the human cell lung atlas here.

Chromosomal Duplication

Chromosomal duplication is a result of extra genetic material within the area of the chromosome. The duplication may have no effect or may be expressed in the phenotype of that individual. Some duplications are thought to be of evolutionary selection. Discover the latest research on chromosomal duplication here.

Human Tumor Atlas

The Human Tumor Atlas is a collaborative project that uses detailed maps of a variety of cancers to investigate cancer development, metastasis, and treatments.

Lung Adenocarcinoma

Lung adenocarcinoma is a type of non-small cell lung cancer and is the most frequent histological type of lung cancer, often triggered by aberrations in a driver oncogene. Here is the latest research.

Interferon Stimulated Genes

Interferon-stimulated gene products take on a number of diverse roles. Collectively, they are highly effective at resisting and controlling pathogens. Discover the latest research on interferon-stimulated genes here.

© 2020 Meta ULC. All rights reserved

Global Transcriptome Analysis of RNA Abundance Regulation by ADAR in Lung Adenocarcinoma

EBioMedicine

Dec 24, 2017

Michael F SharpnackKun Huang

PMID: 29273356

DOI: 10.1016/j.ebiom.2017.12.005

Abstract

Despite tremendous advances in targeted therapies against lung adenocarcinoma, the majority of patients do not benefit from personalized treatments. A deeper understanding of potential therapeutic targets is crucial to increase the survival of patients. One promising target, ADAR, is am...read more

Mentioned in this Paper

Study
Biochemical Pathway
Adenocarcinoma of Lung (Disorder)
Gene Expression Regulation, Neoplastic
Gene Dosage
Apolipoprotein L1
ADAR
Apoptosis, Intrinsic Pathway
APOL1 protein, human
Gene Amplification
8
27

Similar Papers Found In These Feeds

/papers/global-transcriptome-analysis-of-rna-abundance/29273356