Global Trends of Seroprevalence and Universal Screening Policy for Chagas Disease in Donors: a systematic review and meta-analysis

MedRxiv : the Preprint Server for Health Sciences
J. Y. H. KimZulma M Cucunuba


Background: Screening for Trypanosoma cruzi among blood and organ donors is essential to reduce Chagas disease transmission. The World Health Organization (WHO) has prioritised curtailing transmission in blood banks (BBs) and transplantation centres (TCs) by 50% by 2025 and 100% by 2030. This study aims to update the situation on T. cruzi screening strategies in BBs and TCs to evaluate the evolution of seroprevalence and the achievement of screening milestones globally. Methods: We used published articles and government reports on seroprevalence data and screening policies in BBs and TCs across the world. We conducted meta-analyses of T. cruzi seroprevalence estimates by who region, endemicity status, and country, and used meta-regression to identify the covariates influencing the estimates. Publication bias and sensitivity analyses were also conducted. Results: Based on 99 studies and reports and found a global pattern of increased universal screening policies (USPs) in BBs from 1990 to 2018. We found information for 50 countries, of which 44 (88%) have implemented USPs and 21 (42%) achieved 100% coverage by 2015. Out of the 21 Chagas-disease endemic countries, 20 are in advanced USP stages, and 18 achieved 100% coverage by 20...Continue Reading

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