Global View of Candidate Therapeutic Target Genes in Hormone-Responsive Breast Cancer.

International Journal of Molecular Sciences
Annamaria SalvatiGiorgio Giurato

Abstract

Breast cancer (BC) is a heterogeneous disease characterized by different biopathological features, differential response to therapy and substantial variability in long-term-survival. BC heterogeneity recapitulates genetic and epigenetic alterations affecting transformed cell behavior. The estrogen receptor alpha positive (ERα+) is the most common BC subtype, generally associated with a better prognosis and improved long-term survival, when compared to ERα-tumors. This is mainly due to the efficacy of endocrine therapy, that interfering with estrogen biosynthesis and actions blocks ER-mediated cell proliferation and tumor spread. Acquired resistance to endocrine therapy, however, represents a great challenge in the clinical management of ERα+ BC, causing tumor growth and recurrence irrespective of estrogen blockade. Improving overall survival in such cases requires new and effective anticancer drugs, allowing adjuvant treatments able to overcome resistance to first-line endocrine therapy. To date, several studies focus on the application of loss-of-function genome-wide screenings to identify key (hub) "fitness" genes essential for BC progression and representing candidate drug targets to overcome lack of response, or acquired re...Continue Reading

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Citations

Feb 22, 2021·The Journal of Steroid Biochemistry and Molecular Biology·Zunyuan WangZhengrong Shen

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Methods Mentioned

BETA
Dissect
peptide array
protein array
antisense oligonucleotides
immunoprecipitation

Software Mentioned

JACKS
BAGEL
DEMETER2
Ingenuity Pathway Analysis and
DepMap
MAGeCK MLE
SITE
DISCOVER
EnrichmentMap
GeCKO

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