Globostelletins A-I, cytotoxic isomalabaricane derivatives from the marine sponge Rhabdastrella globostellata

Bioorganic & Medicinal Chemistry
Jin LiWen-Han Lin

Abstract

Nine new isomalabaricane-derived natural products, globostelletins A-I (1-9), were isolated from the marine sponge Rhabdastrella globostellata, together with jaspolides F (10), rhabdastrellic acid-A (11), (-)-stellettin E (12), stellettins C (13) and D (14). The structures of these compounds were determined on the basis of extensive spectroscopic analyses and by comparison with the reported data in the literature. The inhibitory activities of compounds 1-12 against human tumor cell lines were evaluated, and their structure-activity relationships were discussed. In addition, rhabdastrellic acid-A (11) showed potent inhibition against HL-60 cells, and it induced the apoptosis of HL-60 cells in M/G2 phase. The mechanism of 11 targeting the ubiquitin-proteasome system, including the regulation of ChT-L and T-L target proteins is discussed.

References

Feb 17, 2009·Trends in Cell Biology·Meike Broemer, Pascal Meier
Apr 21, 2009·Natural Product Reports·Victoriano DomingoAlejandro F Barrero

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Citations

Apr 22, 2015·Journal of Natural Medicines·Caiguo Zhang, Yan Liu
Jan 31, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Roberto MiosoIrma Herrera Bravo de Laguna
Dec 24, 2011·Natural Product Reports·John W BluntMichèle R Prinsep
Apr 22, 2016·Zeitschrift Für Naturforschung. C, a Journal of Biosciences·Wei-Guo XuSheng-An Tang
Feb 7, 2013·Natural Product Reports·Lishu WangYonghong Liu
Feb 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sophia A KolesnikovaValentin A Stonik
Jul 3, 2021·Marine Drugs·Valentin A Stonik, Sophia A Kolesnikova
Jul 3, 2021·Biomedicines·Assunta SaideChiara Lauritano
Oct 28, 2019·Journal of Natural Products·Sophia A KolesnikovaValentin A Stonik

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