Globular Adiponectin Inhibits Breast Cancer Cell Growth through Modulation of Inflammasome Activation: Critical Role of Sestrin2 and AMPK Signaling

Cancers
Duc-Vinh PhamPil-Hoon Park

Abstract

Adiponectin, an adipokine predominantly derived from adipose tissue, exhibits potent antitumor properties in breast cancer cells. However, its mechanisms of action remain elusive. Inflammasomes-intracellular multimeric protein complexes-modulate cancer cell growth in a complicated manner, as well as playing a role in the innate immune system. Herein, we examined the potential role of inflammasomes in the antitumor activity of adiponectin and found that globular adiponectin (gAcrp) significantly suppressed inflammasomes activation in breast cancer cells both in vitro and in vivo conditions, as determined by decreased expression of inflammasomes components, including NOD-like receptor pyrin domain-containing protein 3 (NLRP3) and the apoptosis-associated speck-like protein containing a CARD (ASC), and inhibition of interleukin-1β and caspase-1 activation. Treatment with pharmacological inhibitors of inflammasomes caused decrease in cell viability, apoptosis induction, and G0/G1 cell cycle arrest, suggesting that inflammasomes activation is implicated in the growth of breast cancer cells. In addition, treatment with gAcrp generated essentially similar results to those of inflammasomes inhibitors, further indicating that suppressio...Continue Reading

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Citations

Oct 6, 2020·Frontiers in Oncology·Margherita SonnessaAnita Mangia
Dec 8, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Jie Wang BJunlian Gu
Feb 5, 2021·International Journal of Molecular Sciences·Duc-Vinh Pham, Pil-Hoon Park
Feb 23, 2021·Frontiers in Immunology·Ting-Yi LinChia-Yang Li
Oct 14, 2021·Archives of Physiology and Biochemistry·Zoya TahergorabiMitra Moodi
Nov 7, 2021·Cellular and Molecular Life Sciences : CMLS·Li-Xue WangYong-Ming Yao

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Methods Mentioned

BETA
transfection
immunoprecipitation
Xenograft
PCR
fluorescence microscopy
Profiler
xenografts

Software Mentioned

Graphpad Prism
FlowJo
gAcrp
IHC Profiler
Image J

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