Globular adiponectin regulates energy homeostasis through AMP-activated protein kinase-acetyl-CoA carboxylase (AMPK/ACC) pathway in the hypothalamus.

Molecular and Cellular Biochemistry
Jun-Ping WenLi-xiang Lin

Abstract

Adiponectin is a newly researched adipokine which participates in the regulation of energy homeostasis. AMP-activated protein kinase (AMPK) represents an energy sensor that responds to hormone and nutrition status in vivo and exerts a regulatory effect in the hypothalamus and multiple peripheral tissues. We investigated the possible mechanisms involved in appetite regulation by adiponectin in vitro with GT1-7 cells, a mouse immortalized hypothalamic neuron. The results showed that adiponectin increased the phosphorylation of AMPK, activated AMPK phosphorylated and inactivated acetyl-CoA carboxylase (ACC), and subsequently increased expression of agouti-related peptide (AgRP) mRNA. Our results also indicated that adiponectin had no effect on signal transducer and activator of transcription (STAT3). Together these findings suggest that adiponectin regulated energy homeostasis through the AMPK/ACC pathway but not the JAK/STAT3 pathway in the hypothalamus.

References

Jun 3, 2000·Experimental Brain Research·B PeruzzoE M Rodríguez
Jan 28, 2003·Biochemical Society Transactions·B E KempL A Witters
May 2, 2003·Proceedings of the National Academy of Sciences of the United States of America·Su Gao, M Daniel Lane
Sep 23, 2003·Endocrinology·Neil B RudermanEdward W Kraegen
Oct 9, 2003·Proceedings of the National Academy of Sciences of the United States of America·Zhiyuan HuM Daniel Lane
Jan 20, 2004·Trends in Biochemical Sciences·David Carling
Jan 27, 2004·The Journal of Biological Chemistry·Ulrika AnderssonCaroline J Small
Apr 13, 2004·Nature Medicine·Yong QiRexford S Ahima
Oct 29, 2004·Journal of Cell Science·D Grahame Hardie
Oct 13, 2005·The Journal of Biological Chemistry·Zhiyuan HuM Daniel Lane
Jan 18, 2006·Nature Neuroscience·Wu HeLuciano Rossetti
Apr 11, 2006·Nature Medicine·Tadahiro KitamuraDomenico Accili
May 3, 2006·Proceedings of the National Academy of Sciences of the United States of America·Michael J WolfgangM Daniel Lane
Jun 13, 2006·Trends in Endocrinology and Metabolism : TEM·Blerina KolaMárta Korbonits
Sep 22, 2006·Nature·G J MortonM W Schwartz
Aug 11, 2007·Endocrinology·Miro FaouziHeike Münzberg

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Citations

Jun 13, 2013·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Marwan MannaaMaik Gollasch
Mar 12, 2017·International Journal of Molecular Sciences·Roy Chun-Laam Ng, Koon-Ho Chan
Jun 11, 2014·Annals of Medicine·Cristina ContrerasMiguel López
Aug 12, 2014·BioMed Research International·Ersilia NigroAurora Daniele
May 21, 2016·Nature Reviews. Endocrinology·Miguel LópezCarlos Diéguez
Feb 25, 2011·Reviews in Endocrine & Metabolic Disorders·Pablo Blanco Martínez de MorentinMiguel López
Jul 13, 2018·European Journal of Clinical Investigation·Miguel López
Mar 30, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Jiachen ZhengYang Xi
Feb 25, 2017·European Journal of Endocrinology·Miguel López
Jun 11, 2019·Frontiers in Neuroscience·Romina María Uranga, Jeffrey Neil Keller

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