Globule Leukocytes and Other Mast Cells in the Mouse Intestine

Veterinary Pathology
Peter VogelJerold E Rehg

Abstract

Only 2 major mast cell (MC) subtypes are commonly recognized in the mouse: the large connective tissue mast cells (CTMCs) and the mucosal mast cells (MMCs). Interepithelial mucosal inflammatory cells, most commonly identified as globule leukocytes (GLs), represent a third MC subtype in mice, which we term interepithelial mucosal mast cells (ieMMCs). This term clearly distinguishes ieMMCs from lamina proprial MMCs (lpMMCs) while clearly communicating their common MC lineage. Both lpMMCs and ieMMCs are rare in normal mouse intestinal mucosa, but increased numbers of ieMMCs are seen as part of type 2 immune responses to intestinal helminth infections and in food allergies. Interestingly, we found that increased ieMMCs were consistently associated with decreased mucosal inflammation and damage, suggesting that they might have a role in controlling helminth-induced immunopathology. We also found that ieMMC hyperplasia can develop in the absence of helminth infections, for example, in Treg-deficient mice, Arf null mice, some nude mice, and certain graft-vs-host responses. Since tuft cell hyperplasia plays a critical role in type 2 immune responses to intestinal helminths, we looked for (but did not find) any direct relationship betwe...Continue Reading

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Citations

Dec 20, 2017·Veterinary Pathology·Lauri DiehlVerena K Affolter
Dec 13, 2019·Clinical Reviews in Allergy & Immunology·Daniel Elieh Ali KomiLeonard Bielory
May 8, 2020·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Alyce M MartinDamien J Keating
Aug 14, 2019·Journal of Toxicologic Pathology·Junko SatoMinoru Tsuchitani
Sep 19, 2019·Toxicologic Pathology·Cynthia L Willard-MackCharlotte M Keenan
May 3, 2021·Journal of Veterinary Internal Medicine·Mariya O PitelVerena K Affolter
Jun 30, 2021·Veterinary Ophthalmology·Danica R LucyshynBrian C Leonard
Jul 3, 2021·Frontiers in Immunology·Mariela JiménezEva Salinas

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Methods Mentioned

BETA
transgenic
xenograft

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