Glomerular basement membrane changes in aging nondiabetic and diabetic guinea pigs

Experimental Aging Research
P H LangnerA B Abt

Abstract

Glomerular hyperplasia and thickening of the glomerular basement membrane increase with age in humans and animals. This glomerulopathy can be enhanced by hyperglycemic conditions such as diabetes mellitus. When diabetic guinea pigs were examined by fluorescent microscopy, deposits of a substance similar to immunoglobulin G (IgG) were seen. Comparison with nondiabetic age-matched control animals suggest that glomerulopathy is related to aging, and can be further enhanced by hyperglycemia.

References

May 1, 1976·Diabetes·C M Lang, B L Munger
Apr 1, 1979·Hospital Practice·C B Wilson, F J Dixon
Sep 1, 1976·Kidney International·I Ichikawa, B M Brenner
Mar 1, 1972·Diabetes·N G Westberg, A F Michael
Sep 1, 1968·The Journal of Clinical Investigation·M D SipersteinL L Madison

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Citations

Jan 1, 1983·Experimental Gerontology·M P Cohen, V Yu-Wu
Mar 1, 1986·Environmental Health Perspectives·P O Ganrot
Jan 1, 1983·Experimental Gerontology·M P Cohen, L Ku

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