Glomerular basement membrane length to podocyte ratio in human nephronopenia: implications for focal segmental glomerulosclerosis

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
Dinyar B Bhathena

Abstract

This study aims to probe a possible mechanism for the development of focal segmental glomerulosclerosis (FSGS) in human nephronopenic states. To this end, length (in microns) of the glomerular basement membrane (GBM) covered by the cytoplasm of a podocyte was determined in controls and various congenital and acquired forms of nephronopenia with and without FSGS. Results indicate that for all nephronopenic groups without FSGS, the respective lengths are not significantly different from those of controls. With the exception of long-surviving renal allografts with FSGS, each nephronopenic group with FSGS has a significantly longer length compared with its respective control group without FSGS. Although the corresponding length in long-surviving allografts with FSGS is longer than that in the transplant group without FSGS, the difference does not attain significance. Among all groups with FSGS, the respective GBM lengths are not significantly different among cases of congenital causes of nephronopenia, but are significantly longer than when nephronopenia is acquired, whereas the corresponding lengths among uninephrectomized and transplant groups are not significantly different from one another. These results support the hypothesis ...Continue Reading

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Citations

Jun 1, 2005·Nephron. Experimental Nephrology·Bieke F SchrijversAn S De Vriese
Jul 10, 2012·Journal of the American Society of Nephrology : JASN·Akihiro FukudaRoger C Wiggins
May 12, 2012·The Biochemical Journal·Kristen K McCampbell, Rebecca A Wingert
May 28, 2016·Cell Cycle·Manuel HagenChristoph Daniel
Jun 14, 2014·PloS One·John M CarsonJudith Blaine

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