Glomerular capillary and endothelial cell injury is associated with the formation of necrotizing and crescentic lesions in crescentic glomerulonephritis

Journal of Nippon Medical School = Nippon Ika Daigaku Zasshi
Emiko FujitaShuichi Tsuruoka

Abstract

The associations of glomerular capillary and endothelial injury with the formation of necrotizing and crescentic lesions in cases of crescentic glomerulonephritis (GN) have not been evaluated in detail. Glomerular capillary and endothelial cell injury were assessed in renal biopsy specimens of crescentic GN, including those from patients with anti-neutrophil cytoplasmic autoantibodies (ANCA) -associated GN (n=45), anti-glomerular basement membrane (GBM) GN (n=7), lupus GN (n=21), and purpura GN (n=45) with light and electron microscopy and immunostaining for CD34. In ANCA-associated GN, anti-GBM GN, lupus GN, and purpura GN, almost all active necrotizing glomerular lesions began as a loss of individual CD34-positive endothelial cells in glomerular capillaries, with or without leukocyte infiltration. Subsequently, necrotizing lesions developed and were characterized by an expansive loss of CD34-positive cells with fibrin exudation, GBM rupture, and cellular crescent formation. With electron microscopy, capillary destruction with fibrin exudation were evident in necrotizing and cellular crescentic lesions. During the progression to the chronic stage of crescentic GN, glomerular sclerosis developed with the disappearance of both C...Continue Reading

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Citations

Sep 4, 2015·Journal of the American Society of Nephrology : JASN·Shrikant R MulayHans-Joachim Anders
Nov 23, 2019·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Hernán Trimarchi, Rosanna Coppo
Oct 28, 2019·International Journal of Molecular Sciences·Linlin Wang, Helen Ka Wai Law
Nov 12, 2018·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Xiao-Qing YangYuan Sun
May 8, 2021·Frontiers in Immunology·Xuewei DingXiaojie He

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