Abstract
The associations of glomerular capillary and endothelial injury with the formation of necrotizing and crescentic lesions in cases of crescentic glomerulonephritis (GN) have not been evaluated in detail. Glomerular capillary and endothelial cell injury were assessed in renal biopsy specimens of crescentic GN, including those from patients with anti-neutrophil cytoplasmic autoantibodies (ANCA) -associated GN (n=45), anti-glomerular basement membrane (GBM) GN (n=7), lupus GN (n=21), and purpura GN (n=45) with light and electron microscopy and immunostaining for CD34. In ANCA-associated GN, anti-GBM GN, lupus GN, and purpura GN, almost all active necrotizing glomerular lesions began as a loss of individual CD34-positive endothelial cells in glomerular capillaries, with or without leukocyte infiltration. Subsequently, necrotizing lesions developed and were characterized by an expansive loss of CD34-positive cells with fibrin exudation, GBM rupture, and cellular crescent formation. With electron microscopy, capillary destruction with fibrin exudation were evident in necrotizing and cellular crescentic lesions. During the progression to the chronic stage of crescentic GN, glomerular sclerosis developed with the disappearance of both C...Continue Reading
References
Apr 1, 1981·The Biochemical Journal·F E CohenA F Williams
Jul 1, 1994·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·J C Jennette, R J Falk
Jan 1, 1996·Kidney & Blood Pressure Research·A BohleM Wehrmann
Jul 1, 1998·Nephron·A ShimizuN Yamanaka
Jun 3, 1999·Kidney & Blood Pressure Research·N Yamanaka, A Shimizu
Aug 4, 2001·The American Journal of Pathology·Y MasudaN Yamanaka
Sep 25, 2001·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·J C Jennette, D B Thomas
Apr 23, 2002·Kidney International·Akira ShimizuRobert B Colvin
Jun 18, 2002·Laboratory Investigation; a Journal of Technical Methods and Pathology·Akira ShimizuRobert B Colvin
Jun 29, 2002·Journal of the American Society of Nephrology : JASN·Ryuji OhashiNobuaki Yamanaka
Nov 22, 2002·Journal of the American Society of Nephrology : JASN·Duk-Hee KangRichard J Johnson
Jul 8, 2003·Nephron. Experimental Nephrology·Takahiro MoriNobuaki Yamanaka
Aug 2, 2003·Journal of Cellular Physiology·Carine Michiels
Feb 18, 2004·Internal Medicine·Masaomi Nangaku
Jul 31, 2004·Journal of the American Society of Nephrology : JASN·Dierk H Endemann, Ernesto L Schiffrin
Aug 18, 2004·Lancet·Masataka KuwanaYasuo Ikeda
Oct 7, 2004·Journal of the American Society of Nephrology : JASN·Akira ShimizuYuh Fukuda
Dec 22, 2004·Kidney International·Yasuo IshiiAkira Shimizu
Jan 13, 2006·Kidney International·B LiT Oite
Feb 17, 2006·Journal of the American Society of Nephrology : JASN·Marlies E J ReindersDavid M Briscoe
Sep 27, 2007·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Atsuhiko Kawamoto, Takayuki Asahara
Jul 21, 2010·Laboratory Investigation; a Journal of Technical Methods and Pathology·Yukinari MasudaYuh Fukuda
Aug 3, 2010·Folia Histochemica Et Cytobiologica·Cristina GluhovschiDaniel Cioca
Apr 2, 2011·Clinical and Experimental Immunology·I M Bajema
Sep 3, 2011·Pathology International·Akiko MiiYuh Fukuda
Jul 24, 2012·Human Pathology·Emiko FujitaYuh Fukuda
Aug 21, 2012·Journal of Vascular Nursing : Official Publication of the Society for Peripheral Vascular Nursing·Karen R Fitzgerald
Mar 25, 2014·Autoimmunity Reviews·Gabriella Moroni, Claudio Ponticelli
May 2, 2014·Arthritis & Rheumatology·Masataka Kuwana, Yuka Okazaki
Citations
Apr 26, 2018·Case Reports in Nephrology and Dialysis·Jia XuBeverly E Faulkner-Jones
Feb 13, 2018·Internal Medicine·Masafumi OnoHideo Yasuda
Sep 4, 2015·Journal of the American Society of Nephrology : JASN·Shrikant R MulayHans-Joachim Anders
Nov 23, 2019·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Hernán Trimarchi, Rosanna Coppo
Jan 29, 2019·Clinical and Experimental Nephrology·Yusuke KajimotoAkira Shimizu
Oct 28, 2019·International Journal of Molecular Sciences·Linlin Wang, Helen Ka Wai Law
Nov 12, 2018·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Xiao-Qing YangYuan Sun
Nov 5, 2020·PloS One·Precil Diego Miranda de Menezes NevesLectícia B Jorge
Jan 31, 2016·Human Pathology·Taiko KusanoAkira Shimizu
May 8, 2021·Frontiers in Immunology·Xuewei DingXiaojie He
Jun 27, 2021·Scientific Reports·Momoko AraiYukinao Sakai
Aug 25, 2021·Clinical Science·Sandra Rayego-MateosMarta Ruiz-Ortega