Abstract
There have been several reports of cases of renal amyloidosis with glomerular crescents. However, it is not clear whether the association is fortuitous or pathogenic related. The present study analyzed 105 cases of renal amyloidosis (61 autopsy cases and 44 biopsy cases) and found glomerular crescents in 14 (13.3%) cases. Among the 14 cases with crescents, a female predominance was noted (male: female, 3: 11) and rheumatoid arthritis was the most common primary disease of amyloidosis. Immunohistochemical analysis demonstrated amyloid protein of AA type in 12 cases. According to the histologic classification, there were 11 cases of mesangial nodular type, which was almost exclusively accompanied by AA amyloid deposition. Of note, the incidence of crescents neither correlated with the extent of amyloid deposition nor the presence of nephrotic syndrome. By contrast, localization of amyloid deposition was closely related to crescent formation. Moreover, electron microscopic observation displayed rupture of the glomerular basement membrane at the site of amyloid deposition. Our results indicated that glomerular crescents were more frequently associated with renal amyloidosis than previously appreciated. Rupture of the fragile glomer...Continue Reading
References
Sep 1, 1979·Arthritis and Rheumatism·J A DavisH E Paulus
Jan 1, 1975·Virchows Archiv. A, Pathological Anatomy and Histology·T Watanabe, T Saniter
Jul 1, 1975·Medicine·R A Kyle, E D Bayrd
Jan 1, 1992·Virchows Archiv. A, Pathological Anatomy and Histopathology·N YamaguchiH Shigematsu
May 1, 1991·Japanese Journal of Medicine·S KiyamaT Watanabe
Jan 1, 1989·Nephron·Y OgamiT Watanabe
Feb 1, 1989·Archives of Internal Medicine·J E NaschitzJ H Boss
Jan 1, 1989·Nephron·H ShiikiT Watanabe
Jan 1, 1988·Virchows Archiv. A, Pathological Anatomy and Histopathology·H ShiikiT Watanabe
Jan 1, 1987·Anatomy and Embryology·T Sakai, W Kriz
Jan 1, 1987·Journal of Clinical Apheresis·I VernierJ J Conte
Jan 1, 1984·American Journal of Nephrology·A HaradaT Kimura
Jun 1, 1984·Annals of the Rheumatic Diseases·L D HordonI D Griffiths
Jul 1, 1984·Human Pathology·T WatanabeY Yoshikawa
Dec 1, 1993·Acta Pathologica Japonica·Y ShounoT Watanabe
Jan 1, 1993·American Journal of Nephrology·J AlmirallL Revert
Citations
Aug 5, 2003·Pathology International·Sait Sen, Gülçin Başdemir
Jan 1, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Amy CrosthwaitePeter Mount
May 23, 2012·Pathology International·Hui MengLina Xu
Jan 18, 2013·Indian Journal of Nephrology·Y J Anupama, M Vankalakunti
Sep 1, 2014·Surgical Pathology Clinics·Nasreen Mohamed, Samih H Nasr
Jan 23, 2016·Clinical Kidney Journal·Wisit CheungpasitpornMariam P Alexander
Nov 27, 2015·Néphrologie & thérapeutique·Asmae BzizZaitouna Alhamany
Aug 24, 2007·Human Pathology·Jérôme VerineDominique Droz
May 14, 2020·Acta Clinica Belgica·Lyssa Van De GinsteMarijn M Speeckaert
Nov 1, 2014·CEN Case Reports·Shunsuke YamadaTakanari Kitazono
Mar 13, 2021·Indian Journal of Nephrology·Praveen K EttaSwarnalata Gowrishankar
Apr 7, 2010·Archives of Pathology & Laboratory Medicine·Sait Sen, Banu Sarsik
Aug 18, 2021·Kidney Medicine·Ann A WangAnand Srivastava