Glomerular endothelial cells versus podocytes as the cellular target in diabetic nephropathy

Acta Diabetologica
Silvia Maestroni, Gianpaolo Zerbini

Abstract

It usually takes several years (in some cases, decades) for predisposed individuals to move from the onset of type 1 or type 2 diabetes to the development of microalbuminuria, the first sign of diabetic nephropathy. This long, complication-free, period represents the best possible moment to start a successful preventive strategy (primary prevention) aimed to avoid or at least to postpone the increase of albumin excretion rate. Prevention is based on understanding and counteracting the initial mechanisms leading to the development of the disease and unfortunately, in case of diabetic nephropathy, most of them remain unclear. Little is also known about which, among endothelial cells and podocytes, represent the first glomerular target of the complication. Selective damage of the endothelium or of the podocyte results, as a common consequence, in an increase of albumin excretion rate. Albuminuria by itself cannot therefore be of help to solve the case. Endothelium and podocytes are involved in a continuous cross-talk and by studying the impact of diabetes on this "communication" process it should be possible to obtain some information regarding the weak component of the glomerular filter. Finally, the careful investigation of the ...Continue Reading

References

Apr 1, 1989·European Journal of Biochemistry·R Timpl
Jul 1, 1973·The Journal of Pathology·F Walker
Jan 15, 1997·The Journal of Clinical Investigation·M E PagtalunanT W Meyer
Nov 7, 1999·The American Journal of Pathology·H HolthöferD Kerjaschki
Mar 31, 2000·Nature Medicine·G ThurstonG D Yancopoulos
Sep 9, 2000·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·T NakamuraH Koide
Mar 13, 2003·American Journal of Physiology. Renal Physiology·Stefanie U VogelmannKevin V Lemley
Nov 28, 1964·Lancet·H KEEN, C CHLOUVERAKIS
Oct 27, 2005·Diabetes·Richard J M CowardMoin A Saleem
Apr 7, 2006·American Journal of Physiology. Renal Physiology·Fangxia GuanAlda Tufro
Jan 27, 2007·Pflügers Archiv : European journal of physiology·Sietze ReitsmaMirjam G A oude Egbrink
Sep 7, 2007·American Journal of Physiology. Renal Physiology·Andrew H J SalmonJános Peti-Peterdi
Jan 29, 2008·Current Diabetes Reviews·Fuad N Ziyadeh, Gunter Wolf
Apr 9, 2008·Physiological Reviews·Börje HaraldssonWilliam M Deen
Jan 9, 2009·American Journal of Physiology. Renal Physiology·Simon C Satchell, Filip Braet
Jul 21, 2009·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Yukinari YamaguchiYoshihiko Saito
Aug 7, 2010·Journal of the American Society of Nephrology : JASN·Karen SisonSusan E Quaggin
Oct 5, 2010·Cell Metabolism·Gavin I WelshRichard J M Coward
Jul 2, 2011·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Ana Diez-SampedroAlessia Fornoni
Mar 14, 2012·Experimental Cell Research·Jeffrey H Miner
Apr 3, 2012·Experimental Cell Research·Marya ObeidatBarbara J Ballermann
Sep 22, 2012·Journal of the American Society of Nephrology : JASN·Darren A YuenAndrew Advani
Dec 14, 2012·American Journal of Physiology. Renal Physiology·Wilhelm KrizKevin V Lemley
Dec 26, 2012·Proceedings of the National Academy of Sciences of the United States of America·Fabian BockBerend Isermann
May 21, 2013·Journal of the American Society of Nephrology : JASN·M Luiza CaramoriMichael Mauer
Sep 4, 2013·Nature Reviews. Nephrology·Florian GrahammerTobias B Huber
Sep 7, 2013·Journal of the American Society of Nephrology : JASN·Cecile Dessapt-BaradezLuigi Gnudi
Oct 2, 2013·Nature Reviews. Nephrology·Simon Satchell
Apr 18, 2014·The New England Journal of Medicine·Edward W GreggLinda Geiss

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Citations

Jun 16, 2019·Medicina·Guido GembilloDomenico Santoro
Apr 29, 2020·International Journal of Molecular Sciences·Anton I KorbutVadim V Klimontov
Feb 23, 2020·Journal of the American Society of Nephrology : JASN·Virginie RoyalLaura Barisoni
May 30, 2019·American Journal of Physiology. Renal Physiology·Ayesha GhayurPeter J Margetts
Feb 13, 2021·Frontiers in Pharmacology·Lili ShengShougang Zhuang
May 6, 2021·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Luca ValsecchiGianpaolo Zerbini
Jan 19, 2022·Journal of Cell Communication and Signaling·Shan JiangPing Luo

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