PMID: 9543595Apr 17, 1998Paper

Glomerular enlargement in the progression of mesangial proliferative glomerulonephritis

Clinical Nephrology
S Daimon, I Koni

Abstract

A close association between glomerular hypertrophy and subsequent sclerosis had been demonstrated in diverse animal and human studies. We investigated the relationship between the glomerular volume and glomerular constituents (mesangial matrix, mesangial cells and capillary lumens) in human mesangial proliferative glomerulonephritis (GN). The data were obtained from glomeruli in the specimens of 23 patients undergoing repeat renal biopsies. Glomerular volume and glomerular constituents of each patient were obtained by averaging those of all glomeruli in each specimen. The interval from the first biopsy to the second was 51.2 +/- 6.8 months and the number of glomeruli included in each specimen was 16 +/- 1. Between glomerular volume and fractional mesangial volume, three patterns were recognized. In 8 of 23 patients glomerular volume and fractional mesangial volume were increased in the second biopsy (Group A). In 12 of 23 patients glomerular volume was decreased and fractional mesangial volume increased in the second biopsy (Group B), and in 3 of 23 patients glomerular volume was increased and fractional mesangial volume decreased in the second biopsy (Group C). One patient who underwent renal biopsy three times shifted from Gr...Continue Reading

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