Glomerular expression of Fas ligand and Bax mRNA in lupus nephritis

Autoimmunity
I Badillo-AlmarázR Herrera-Esparza

Abstract

The current studies were carried out to determine the expression of Fas ligand and Bax in kidneys from lupus nephritis as possible indicators of apoptosis. Twenty-four kidney biopsies from patients with lupus nephritis and 30 normal controls were studied for FasL and Bax gene expression by fluorescent in situ hybridization. Seventy percent of the lupus biopsies displayed FasL or Bax mRNAs. These genes were mainly expressed in biopsies with higher activity indices. In contrast, neither of these mediators was detected in normal glomeruli. These data suggest that FasL and Bax are up-regulated in lupus nephritis and may play a pathogenic role through apoptotic cascades.

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Citations

Jun 3, 2005·Current Opinion in Nephrology and Hypertension·Jeremy Hughes, John S Savill
Jan 17, 2008·Arthritis Research & Therapy·Seetha U MonradMariana J Kaplan
Dec 17, 2014·International Journal of Nephrology·Juan José Bollain-Y-GoytiaRafael Herrera-Esparza
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Jun 16, 2009·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Na LuoYuzhang Wu
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Jan 12, 2021·Expert Review of Proteomics·Ting ZhangChandra Mohan

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Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis