PMID: 1199812Nov 1, 1975Paper

Glomerular filtration rate and renal plasma flow in patients with essential hypertension before and after treatment with alprenolol

Acta Medica Scandinavica
E B Pedersen

Abstract

In 25 patients with essential hypertension, the renal plasma flow RPF), glomerular filtration rate (GFR) and BP have been measured before and after one month's treatment with alprenolol. The patients were divided into two groups according to age. Group 1 consisted of 10 patients with mild hypertension under 35 years of age, group 2 of 15 patients over the age of 35 with moderate hypertension. A markedly greater lowering of BP was measured in group 1 than in group 2. There were no changes in RPF or GFR after alprenolol treatment and no differences in these parameters were observed between the two groups either before or after treatment. Group 1 displayed significantly lower renal vascular resistance (RVR) than group 2 both before and after treatment, and alprenolol treatment resulted in a slight reduction of RVR in group 1, but not in group 2. The difference between the two groups with respect to the antihypertensive effect of alprenolol and the RVR may possibly be due to the fact that the patients in group 2 had more pronounced structural vascular alterations than those in group 1.

References

Nov 1, 1969·Acta Medica Scandinavica·C Furberg, G Michaelson
Nov 1, 1969·Acta Medica Scandinavica·G Tibblin, B Ablad
Jun 1, 1973·Acta Medica Scandinavica·G Berglund, L Hansson
Sep 1, 1971·Scandinavian Journal of Clinical and Laboratory Investigation·C E Mogensen
Jan 4, 1969·British Medical Journal·B N Prichard, P M Gillam
Sep 19, 1964·British Medical Journal·B N PRICHARD, P M GILLAM

❮ Previous
Next ❯

Citations

Jan 1, 1986·European Journal of Clinical Pharmacology·L R KrusellO Lederballe Pedersen
Feb 1, 1979·British Journal of Clinical Pharmacology·R M Pearson
Jan 1, 1982·British Journal of Clinical Pharmacology·A PasternackL Pöyhönen
Nov 1, 1980·Kidney International·M A Weber, J I Drayer

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.