PMID: 6496147Sep 1, 1984

Glomerular filtration rate during lithium therapy. A longitudinal study

Acta Psychiatrica Scandinavica
S B Jensen, H Rickers


In order to investigate the side effect of lithium on renal function the glomerular filtration rate (GFR) was measured before (to) and after a mean of 16.5 months (t1) (range 12-25 months) lithium treatment in 13 consecutive patients aged 32-67 years (mean age 46 years). The patients had a normal renal function before the treatment was started; none of them had previously been treated with lithium. During treatment GFR (ml/min) fell from 101.9 to 98.3 which was not significant. However, standard-GFR (ml/min/1.73 m2) fell from 88.4 to 84.8 (P less than 0.05) mainly due to a significant rise in body weight and estimated surface area during treatment. No significant changes appeared in plasma creatinine. It is concluded that lithium therapy for a mean of 16.5 months does not affect the glomerular filtration rate; but considerably longer observations of GFR during lithium therapy should be done by means of a reliable GFR measurement method.


Jul 1, 1979·The British Journal of Psychiatry : the Journal of Mental Science·R HällgrenK Hellsing
Jun 2, 1979·British Medical Journal·R P HullinD B Morgan
Nov 1, 1979·Acta Psychiatrica Scandinavica·P VestergaardM Schou
Jan 1, 1977·Scandinavian Journal of Urology and Nephrology·J Bröchner-MortensenP Rodbro
Sep 1, 1977·Kidney International·J HestbechS Olsen
Nov 1, 1972·Scandinavian Journal of Clinical and Laboratory Investigation·J Bröchner-Mortensen
Feb 1, 1983·Psychological Medicine·S P TyrerB Shopsin
Apr 1, 1981·Acta Psychiatrica Scandinavica·P Vestergaard, A Amdisen
Jul 1, 1980·The American Journal of Psychiatry·R H GernerM A Kirschenbaum
Mar 1, 1981·The American Journal of Psychiatry·J R DepauloD G Sapir


Jan 1, 1988·Journal of Psychiatric Research·M Schou
Mar 1, 1997·Journal of Affective Disorders·H CoşkunolI Tuğlulaŕ
Nov 1, 1989·Psychological Medicine·D G Waller, J G Edwards
May 21, 2010·Journal of Affective Disorders·John TredgetGeorge Kirov
Apr 28, 2009·Journal of Psychopharmacology·R PaulC Kelly
Apr 3, 2012·Journal of Geriatric Psychiatry and Neurology·Soham RejKenneth Shulman

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