PMID: 6496147Sep 1, 1984

Glomerular filtration rate during lithium therapy. A longitudinal study

Acta Psychiatrica Scandinavica
S B Jensen, H Rickers

Abstract

In order to investigate the side effect of lithium on renal function the glomerular filtration rate (GFR) was measured before (to) and after a mean of 16.5 months (t1) (range 12-25 months) lithium treatment in 13 consecutive patients aged 32-67 years (mean age 46 years). The patients had a normal renal function before the treatment was started; none of them had previously been treated with lithium. During treatment GFR (ml/min) fell from 101.9 to 98.3 which was not significant. However, standard-GFR (ml/min/1.73 m2) fell from 88.4 to 84.8 (P less than 0.05) mainly due to a significant rise in body weight and estimated surface area during treatment. No significant changes appeared in plasma creatinine. It is concluded that lithium therapy for a mean of 16.5 months does not affect the glomerular filtration rate; but considerably longer observations of GFR during lithium therapy should be done by means of a reliable GFR measurement method.

References

Jul 1, 1979·The British Journal of Psychiatry : the Journal of Mental Science·R HällgrenK Hellsing
Jun 2, 1979·British Medical Journal·R P HullinD B Morgan
Nov 1, 1979·Acta Psychiatrica Scandinavica·P VestergaardM Schou
Jan 1, 1977·Scandinavian Journal of Urology and Nephrology·J Bröchner-MortensenP Rodbro
Sep 1, 1977·Kidney International·J HestbechS Olsen
Nov 1, 1972·Scandinavian Journal of Clinical and Laboratory Investigation·J Bröchner-Mortensen
Feb 1, 1983·Psychological Medicine·S P TyrerB Shopsin
Apr 1, 1981·Acta Psychiatrica Scandinavica·P Vestergaard, A Amdisen
Jul 1, 1980·The American Journal of Psychiatry·R H GernerM A Kirschenbaum
Mar 1, 1981·The American Journal of Psychiatry·J R DepauloD G Sapir

Citations

Jan 1, 1988·Journal of Psychiatric Research·M Schou
Mar 1, 1997·Journal of Affective Disorders·H CoşkunolI Tuğlulaŕ
Nov 1, 1989·Psychological Medicine·D G Waller, J G Edwards
May 21, 2010·Journal of Affective Disorders·John TredgetGeorge Kirov
Apr 28, 2009·Journal of Psychopharmacology·R PaulC Kelly
Apr 3, 2012·Journal of Geriatric Psychiatry and Neurology·Soham RejKenneth Shulman

Related Concepts

Krebiozen
Glomerular Filtration Rate
Kidney
Lithium
Longitudinal Survey

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