Glomerular Filtration Rate is Associated with Hemorrhagic Transformation in Acute Ischemic Stroke Patients without Thrombolytic Therapy

Chinese Medical Journal
Ming-Su LiuGuang-Qin Li

Abstract

Whether there is a relationship between glomerular filtration rate (GFR) and hemorrhagic transformation (HT) after acute ischemic stroke (AIS) is still under debate. The aim of our study was to determine whether the GFR level is a predictor of HT in AIS patients without thrombolytic therapy (TT). Consecutive AIS patients without TT were included in this prospective study from January 2014 to December 2016 in the First Affiliated Hospital of Chongqing Medical University. We divided them into two groups (HT and non-HT group) and meticulously collected baseline characteristics and laboratory and imaging data of interested individuals. Multivariate regression analysis was performed to assess the correlation between GFR and HT in stroke patients without TT. Among 426 consecutive patients, 74 (17.3%) presented HT (mean age: 65 ± 12 years, number of male patients: 47) on the follow-up scans. In multivariate regression analysis, HT was significantly associated with low GFR (odds ratio [OR] = 3.708, confidence interval [CI] = 1.326-10.693, P = 0.013), atrial fibrillation (AF; OR = 2.444, CI = 1.087-5.356, P = 0.027), large cerebral infarction (OR = 2.583, CI = 1.236-5.262, P = 0.010), and hypoalbuminemia (HA; OR = 4.814, CI = 1.054-22.1...Continue Reading

References

Apr 6, 2002·Stroke; a Journal of Cerebral Circulation·Ludmila BelayevMyron D Ginsberg
Apr 22, 2004·Nature Reviews. Neuroscience·Costantino Iadecola
Jul 5, 2005·Thrombosis Research·Avtar S SohalDarin Treleaven
Sep 22, 2006·Journal of the American Society of Nephrology : JASN·Ying-Chun MaHai-Yan Wang
Oct 14, 2006·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·L KerenyiL Csiba
Feb 3, 2009·Stroke; a Journal of Cerebral Circulation·Gilad YahalomDavid Tanne
Sep 30, 2010·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·A John CammUNKNOWN ESC Committee for Practice Guidelines
Oct 16, 2010·Stroke; a Journal of Cerebral Circulation·Youngchai KoHee-Joon Bae
Nov 4, 2010·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Maria Ramos-FernandezLatha G Stead
Jan 28, 2012·Neurology·J H ParkP B Gorelick
Oct 17, 2012·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Katrin Uhlig, Kai-Uwe Eckardt
Feb 23, 2013·Cerebrovascular Diseases·Jung-Gon LeeHye-Won Hwang
Mar 5, 2013·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Patrick D Lyden
Mar 16, 2013·International Journal of Stroke : Official Journal of the International Stroke Society·Hans T H TuUNKNOWN EPITHET-DEFUSE Investigators
Mar 26, 2013·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·E B MarshR F Gottesman
Sep 5, 2013·Stroke; a Journal of Cerebral Circulation·Serdar TütüncüChristian H Nolte
Nov 10, 2013·Stroke; a Journal of Cerebral Circulation·Ji Man HongKiwon Lee
Nov 28, 2013·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Glen C JicklingFrank R Sharp
May 9, 2014·Stroke; a Journal of Cerebral Circulation·Elisabeth B MarshRafael H Llinas
Jul 23, 2014·Transplantation·Paige M PorrettMatthijs ter Horst
Aug 6, 2014·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·M LaibleR Veltkamp
Sep 5, 2014·Interventional Neurology·May NourDavid S Liebeskind
Sep 10, 2014·World Neurosurgery·Naoki Nitta, Kazuhiko Nozaki
Oct 16, 2014·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Chunyan LeiYanchao Chen
Jan 8, 2015·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Songlin YuUNKNOWN UCLA Stroke Investigators
Mar 31, 2015·Stroke; a Journal of Cerebral Circulation·Yang GuoMin Lou
Sep 5, 2015·Neuroradiology·Alexander D HorschUNKNOWN DUST investigators
Apr 28, 2016·Stroke; a Journal of Cerebral Circulation·Ana Inês MartinsLuís Cunha
Jun 20, 2016·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Dipender GillArindam Kar
Dec 17, 2016·Journal of Atherosclerosis and Thrombosis·Masato KanazawaTakayoshi Shimohata
Jan 25, 2017·Experimental Gerontology·David Yang-Wei FannThiruma V Arumugam
May 10, 2017·The AAPS Journal·Ali Ehsan SifatThomas J Abbruscato
Jun 24, 2017·International Journal of Stroke : Official Journal of the International Stroke Society·Derek HaydenPeter J Kelly

❮ Previous
Next ❯

Citations

Nov 15, 2018·Chinese Medical Journal·Jiao QinLi-Jian Tao
Apr 21, 2020·Stroke Research and Treatment·Sirichai ChusiriChankit Puttilerpong
Dec 21, 2020·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Xin WangLijuan Zhang
May 1, 2021·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Sara Stern-Nezer

❮ Previous
Next ❯

Software Mentioned

SPSS

Related Concepts

Related Feeds

Atrial Filbrillation

Atrial fibrillation refers to the abnormal heart rhythm characterized by rapid and irregular beating of the atria. Here is the latest research.

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.