PMID: 9543366Apr 16, 1998Paper

Glomerular growth in childhood focal segmental glomerulosclerosis

Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
J Y KimH S Lee

Abstract

Studies have suggested that glomerular size increases in childhood minimal lesion with age or growth. To examine whether mean glomerular volume (MGV) of pediatric patients with focal segmental glomerulosclerosis (FSGS) also increases with age and whether FSGS by itself can contribute to glomerular hypertrophy, we studied 67 children (40 boys, 27 girls) with primary FSGS and 95 children (68 boys, 27 girls) with minimal lesion by morphometry. FSGS patients had segmental sclerosis affecting 17.1% +/- 14.8% of the glomeruli. The percentage of segmental glomerulosclerosis was not related to age. MGV increased with age in the FSGS patients (r2 = 0.36, P < 0.001) and in the minimal lesion patients (r2 = 0.37, P < 0.001). MGV of children with FSGS is significantly larger than that of the minimal lesion group [(14.8 +/- 5.7) x 10(5) microm3 vs. (12.1 +/- 3.7) x 10(5) microm3, P < 0.001]. Multiple regression estimates suggest that the FSGS lesion affects MGV independently (P < 0.001). The volume density of mesangium and the volume density of cortical interstitium were significantly greater in the FSGS patients than in the minimal lesion patients (P < 0.001). These results indicate that MGV of pediatric FSGS patients increases with age an...Continue Reading

Citations

Sep 12, 2006·Pathology, Research and Practice·Irina-Draga Caruntu, Adrian Covic
May 15, 2012·Journal of the American Society of Nephrology : JASN·Alberto MagnascoGian Marco Ghiggeri
Feb 17, 2000·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·A B Fogo
Dec 3, 2021·Journal of the American Society of Nephrology : JASN·Linus ButtThomas Benzing

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