Glomerular hemodynamic effects of late pregnancy in rats with experimental membranous glomerulonephropathy.

Journal of the American Society of Nephrology : JASN
C BaylisW G Couser

Abstract

In these studies, the Fx1A model of accelerated, passive Heymann nephritis was used to produce membranous glomerulonephropathy. Female rats were studied at 7 wk after the administration of the Fx1A antibody either in the virgin state or in late pregnancy. The goals of these experiments were to determine whether preexisting membranous glomerulonephropathy compromises the pregnancy and whether the pregnancy acutely worsens the renal function. Virgin rats with membranous glomerulonephropathy developed massive proteinuria and exhibited glomerular capillary hypertension but without declines in GFR. In late pregnancy, there was no worsening of the proteinuria and glomerular blood pressure fell to normal values. Both afferent and efferent arteriolar resistances increased in pregnant rats with membranous glomerulonephropathy compared with virgins, leading to falls in glomerular plasma flow and single-nephron GFR. There were no histologic abnormalities in the glomeruli of either virgin or late pregnant rats with membranous glomerulonephropathy, and both groups exhibited similar immunoglobulin G and complement deposits. Up to Day 19 (term is 22 days), the pregnancy in rats with membranous glomerulonephropathy appeared uneventful. Thus, t...Continue Reading

Citations

Mar 5, 2003·Advances in Renal Replacement Therapy·Chris Baylis
Sep 11, 1999·The Journal of Laboratory and Clinical Medicine·M M FaasG A Schuiling
Dec 18, 2001·Journal of Clinical Ultrasound : JCU·H MiyakeT Araki
Apr 2, 1999·Seminars in Perinatology·E PodjarnyG Losonczy
Jun 18, 2010·Clinical and Experimental Nephrology·Miwa IgarashiShunji Suzuki

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