PMID: 7241881Mar 1, 1981Paper

Glomerular hemodynamics in experimental diabetes mellitus

Kidney International
T H HostetterB M Brenner


Micropuncture studies were performed in three groups of euvolemic male Munich-Wistar rats: 8 control rats, 7 severely hyperglycemic rats made diabetic with streptozotocin (60 mg/kg, i.v.), and 6 moderately hyperglycemic rats made diabetic by the same method but given 2 U of NPH insulin daily. Glucose concentrations at the time of micropuncture study averaged 115 +/- (sem) 10, 565 +/- 12, and 375 +/- 23 mg/dl, respectively. Single nephron GFR (SNGFR) values were significantly lower (28.8 +/- 1.9nl/min) in severely hyperglycemic rats than they were in controls (48.9 +/- 3.8). This reduction in SNGFR was due mainly to a fall in glomerular plasma flow rate ((Q(A)). In contrast, moderately hyperglycemic rats exhibited glomerular hyperfiltration, with SNGFR values averaging 69.0 +/- 8.0 nl/min. This hyperfiltration, with resulted from elevations in values for Q(A) and glomerular transcapillary hydraulic pressure difference (delta P) to levels significantly above control. These alterations in SNGFR in severely hyperglycemic and moderately hyperglycemic rats, relative to controls, were paralleled by changes in whole kidney GFR and mimic the changes in GFR observed in diabetic patients with analogous degrees of hyperglycemia. Measuremen...Continue Reading


Dec 1, 1976·Clinical Science and Molecular Medicine·K Seyer-Hansen
Dec 15, 1977·The New England Journal of Medicine·P V HalushkaJ A Colwell
Aug 1, 1972·Kidney International·M Levy, N L Starr
Apr 1, 1970·The Journal of Clinical Investigation·R H UngerA M Eisentraut
Jun 1, 1962·The Journal of Clinical Investigation·J CORVILAINA BERGANS

❮ Previous
Next ❯


Mar 1, 1991·Diabetes/metabolism Reviews·G PuglieseJ R Williamson
Jun 26, 2001·Diabetes/metabolism Research and Reviews·N KasaiT Suda
Dec 1, 1990·Journal of Applied Toxicology : JAT·T Seefeldt, D C Houghton
Jun 1, 1982·Diabetologia·J S Christiansen, H H Parving
Jun 1, 1994·Diabetologia·L SchaeferA Heidland
Sep 1, 1991·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·H W SeyberthN Gordjani
Apr 1, 1995·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·F ChiarelliG Morgese
Jan 1, 1990·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·M LarsenH Lund-Andersen
Jan 1, 1991·Virchows Archiv. A, Pathological Anatomy and Histopathology·H Wehner, G Nelischer
Sep 1, 1989·Klinische Wochenschrift·A M el Nahas
Jul 10, 2008·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Shivaram Hegde, Malcolm G Coulthard
Jun 28, 2005·Clinical and Experimental Nephrology·Genjiro Kimura
Aug 18, 2012·Current Hypertension Reports·Michio Fukuda, Genjiro Kimura
Jan 1, 1995·Diabetes Research and Clinical Practice·K P Patel, P L Zhang
Oct 1, 1993·European Journal of Pharmacology·Y X Wang, D P Brooks

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.