PMID: 7241881Mar 1, 1981Paper

Glomerular hemodynamics in experimental diabetes mellitus

Kidney International
T H HostetterB M Brenner

Abstract

Micropuncture studies were performed in three groups of euvolemic male Munich-Wistar rats: 8 control rats, 7 severely hyperglycemic rats made diabetic with streptozotocin (60 mg/kg, i.v.), and 6 moderately hyperglycemic rats made diabetic by the same method but given 2 U of NPH insulin daily. Glucose concentrations at the time of micropuncture study averaged 115 +/- (sem) 10, 565 +/- 12, and 375 +/- 23 mg/dl, respectively. Single nephron GFR (SNGFR) values were significantly lower (28.8 +/- 1.9nl/min) in severely hyperglycemic rats than they were in controls (48.9 +/- 3.8). This reduction in SNGFR was due mainly to a fall in glomerular plasma flow rate ((Q(A)). In contrast, moderately hyperglycemic rats exhibited glomerular hyperfiltration, with SNGFR values averaging 69.0 +/- 8.0 nl/min. This hyperfiltration, with resulted from elevations in values for Q(A) and glomerular transcapillary hydraulic pressure difference (delta P) to levels significantly above control. These alterations in SNGFR in severely hyperglycemic and moderately hyperglycemic rats, relative to controls, were paralleled by changes in whole kidney GFR and mimic the changes in GFR observed in diabetic patients with analogous degrees of hyperglycemia. Measuremen...Continue Reading

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Citations

Mar 1, 1991·Diabetes/metabolism Reviews·G PuglieseJ R Williamson
Jun 26, 2001·Diabetes/metabolism Research and Reviews·N KasaiT Suda
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Aug 18, 2012·Current Hypertension Reports·Michio Fukuda, Genjiro Kimura
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Oct 1, 1993·European Journal of Pharmacology·Y X Wang, D P Brooks

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