Glomerular hyperfiltration during sympathetic nervous system activation in early essential hypertension.

Journal of the American Society of Nephrology : JASN
R E SchmiederF C Luft

Abstract

Glomerular hyperfiltration may be important for the development of essential hypertension. Both the renin-angiotensin system and the sympathetic nervous system influence renal hemodynamic regulation. To test the hypothesis that glomerular hyperfiltration can be unmasked by sympathetic nervous system activation, renal hemodynamics and humoral components of the renin-angiotensin system were examined at rest and during mental stress in 45 young normotensive healthy subjects and 37 young people with mild essential hypertension. GFR and renal plasma flow (RPF) were determined with inulin and para-aminohippuric acid clearance at rest and during stress. At rest, RPF, GFR, filtration fraction, plasma renin activity, angiotensin (Ang) II concentrations, and serum aldosterone values were similar in normotensive and hypertensive subjects. After stress, blood pressure increased (P < 0.01), but this was nearly identical in normotensive and hypertensive subjects (7.05 +/- 6.9 versus 7.03 +/- 4.6 mmHg, NS). The decrease in RPF (-27 +/- 54 versus -22 +/- 25 ml/min per 1.73 m2, NS) was also similar in the two groups. In contrast, the increase in GFR (+ 10.5 +/- 7.2 versus 6.08 +/- 5.7 ml/min per 1.73 m2, P < 0.001) and filtration fraction (+2.4...Continue Reading

Citations

Jul 21, 1999·Journal of Cardiovascular Pharmacology·J P FauvelM Laville
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Aug 27, 2005·Journal of the American Society of Nephrology : JASN·Roland E SchmiederChristian Delles
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Jul 28, 2010·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Andrew S Levey, Holly Kramer
Jan 29, 2011·Diabetes·Christian OttRoland E Schmieder

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